Diabetes, Obesity and the Gut Microbiome
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: closed (31 October 2017) | Viewed by 73304
Special Issue Editors
Interests: nutrition; inflammatory bowel disease; digital health; technology; epidemiology
Special Issues, Collections and Topics in MDPI journals
Interests: clinical nutrition; gastroenterology; inflammatory bowel disease; nutrition assessment
Special Issue Information
Dear Colleagues,
The gut microbiome is an interactive network of trillions of microbes that synergize to provide epigenetic regulation of the host and impacting a number of crucial physiological functions. Establishment of the gut microbiome is influenced by the mode of birth, breastfeeding, provision of prebiotic foods, antibiotics, host genetics, and more. Environmental factors cause perturbations in the biodiversity of the gut microbial communities occur throughout the lifecycle, however, the interplay between diet and host genetics determines the outcome: health or disease. Diabetes and obesity are complex chronic diseases that have reduced gut microbial biodiversity that contribute towards their pathophysiologies including insulin resistance, systemic inflammation, increased gut permeability, appetite dysregulation, distorted thermodynamics among other changes. Bacteria causing weight gain are thought to induce the expression of genes related to lipid and carbohydrate metabolism thereby leading to greater energy harvest from the diet. Intricate fecal transplantation experiments in genetically manipulated mice have exquisitely demonstrated the interaction of genes and environment to produce metabolic outcomes that can either prevent to promote these chronic diseases. Novel therapies for these chronic diseases will be advanced by a deeper understanding of epigenetic modulation of host metabolism by the gut microbiome in health and in obesity and diabetes.
In this Special Issue, we would like to invite submissions of original research or review articles on any topic related to “Diabetes, Obesity, and the Gut Microbiome”. We look forward to receiving your contributions.
Dr. Gerard E. Mullin
Prof. Laura Matarese
Guest Editors
Manuscript Submission Information
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Keywords
- Gut Microbiome
- Obesity
- Diabetes
- Inflammation
- Insulin resistance
- Epigenetics
- Animal Models
- Probiotics
- Prebiotics
- Fecal transplantation
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