Ancient DNA and Human Evolution

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Population and Evolutionary Genetics and Genomics".

Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 4360

Special Issue Editors


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Guest Editor
1. Australian Centre for Ancient DNA, School of Biological Sciences, Environment Institute, The University of Adelaide, Adelaide, SA 5005, Australia
2. National Centre for Indigenous Genomics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia
Interests: ancient DNA; paleogenomics; evolutionary genomics; population genomics; pangenomics; indigenous genomics

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Guest Editor
Human Paleogenomics Lab, Anthropology Department, University of California Santa Cruz, Santa Cruz, CA 95064, USA
Interests: ancient DNA; paleogenomics; evolutionary genomics; South America; human ecology; archaeology; anthropology

Special Issue Information

Dear Colleagues,

Over the past decade, human ancient DNA datasets have reached genomic scale for thousands of individuals, including whole-genome sequences from extinct human species such as Neanderthals and Denisovans. Such datasets provide detailed information about the demographic history of populations around the world, and allow tracking genetic variants through space and time to study adaptation to changing environments and lifestyles as it happens. Associated biological insights include the reconstruction of past human microbiomes, pathogen genomes, and epigenomic maps. All in all, the study of human and their microorganisms ancient DNA keep on changing radically our understanding of human evolutionary history.

The aim of this Special Issue is to provide reviews and original research articles on all aspects of ancient DNA in relation to human evolution, including local and global demography using uniparental and/or autosomal genetic markers, admixture events, adaptation to shifting environments and lifestyles, and co-evolution with microorganisms and pathogens.

Dr. Bastien Llamas
Dr. Lars Fehren-Schmitz
Guest Editors

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Keywords

  • ancient DNA
  • paleogenomics
  • human evolution
  • molecular anthropology

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Published Papers (1 paper)

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Review

16 pages, 1822 KiB  
Review
Epigenomic Modifications in Modern and Ancient Genomes
by Laura Niiranen, Dawid Leciej, Hanna Edlund, Carolina Bernhardsson, Magdalena Fraser, Federico Sánchez Quinto, Karl-Heinz Herzig, Mattias Jakobsson, Jarosław Walkowiak and Olaf Thalmann
Genes 2022, 13(2), 178; https://doi.org/10.3390/genes13020178 - 20 Jan 2022
Cited by 9 | Viewed by 3547
Abstract
Epigenetic changes have been identified as a major driver of fundamental metabolic pathways. More specifically, the importance of epigenetic regulatory mechanisms for biological processes like speciation and embryogenesis has been well documented and revealed the direct link between epigenetic modifications and various diseases. [...] Read more.
Epigenetic changes have been identified as a major driver of fundamental metabolic pathways. More specifically, the importance of epigenetic regulatory mechanisms for biological processes like speciation and embryogenesis has been well documented and revealed the direct link between epigenetic modifications and various diseases. In this review, we focus on epigenetic changes in animals with special attention on human DNA methylation utilizing ancient and modern genomes. Acknowledging the latest developments in ancient DNA research, we further discuss paleoepigenomic approaches as the only means to infer epigenetic changes in the past. Investigating genome-wide methylation patterns of ancient humans may ultimately yield in a more comprehensive understanding of how our ancestors have adapted to the changing environment, and modified their lifestyles accordingly. We discuss the difficulties of working with ancient DNA in particular utilizing paleoepigenomic approaches, and assess new paleoepigenomic data, which might be helpful in future studies. Full article
(This article belongs to the Special Issue Ancient DNA and Human Evolution)
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