Male Infertility: From Genes to Genomes

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Population and Evolutionary Genetics and Genomics".

Deadline for manuscript submissions: closed (20 April 2022) | Viewed by 1022

Special Issue Editors

Guest Editor Assistant
Department of Biochemistry and Biotechnology, University of Thessaly, 41221 Larissa, Greece
Interests: male infertility; animal genomics; evolution; genetics; non-coding RNAs

Special Issue Information

Dear Colleagues,

Infertility is defined according to the WHO as the inability to conceive after at least 12 months of regular, unprotected sexual intercourse. It is an alarming global health issue, as it is estimated that 8–12% of couples of reproductive age suffer from infertility. The male factor interestingly contributes to 50% of all cases.

Male infertility is a complex disorder affected by an interplay between genetic and environmental factors. A large proportion of male infertility cases are also idiopathic. Semen analysis remains the cornerstone for its diagnosis, but today, in the era of genomics, next-generation sequencing (NGS) technologies, such as whole-exome and genome sequencing, offer the opportunity to simultaneously study numerous genes and identify new biomarkers. Additionally, it is estimated that approximately 10% of the human genome is involved in reproduction. Discoveries on the role of small RNAs and microRNAs in the spermatogenesis process are promising for the understanding of the mechanisms behind male infertility, too.

Thus, this Special Issue of Genes, entitled “Male Infertility: From Genes to Genomes”, aims to contribute to the identification of new genetic variants and genetic risk alleles associated with male infertility as well as to provide readers with updated information regarding recent advances in the field. In this regard, original research articles and reviews are both welcome.

Prof. Dr. Zissis Mamuris
Guest Editor
Maria-Anna Kyrgiafini
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • male infertility
  • biomarkers
  • semen analysis
  • spermatogenesis
  • genetic variants
  • next-generation sequencing (NGS)

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop