Hox and TALE Gene Function in Evolution, Development, and Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 4081
Special Issue Editor
Interests: HOX genes; TALE-homeobox genes; transcriptional regulation; cancer molecular biology; developmental molecular biology; post-transcriptional regulation; miRNAs; lncRNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The family of evolutionarily highly conserved Hox genes, since their discovery almost four decades ago, has attracted, and continues to attract, much interest. This is not only because of the crucial role played by this unique gene family in the development of the main body axis of essentially all studied animal species, but also because of its involvement in a number of human disorders, ranging from genetic diseases to cancer.
In this upcoming Special Issue of Genes, we aim to cover the most recent progress in the study of the function Hox genes and of their close partners, the TALE homeobox genes. Thus, contributions describing advances in our understanding of the regulation of Hox and/or TALE gene expression, of the transcriptional regulation by Hox and/or TALE proteins, of post-transcriptional mechanisms affecting Hox and/or TALE gene function that involve non-coding RNAs (miRNAs, lncRNAs), and of epigenetic regulatory mechanisms controlling Hox and/or TALE expression, from an evo–devo perspective and/or in developmental or disease processes, are all very welcome.
Contributions can be in the form of research articles, reviews, and the description of new methodologies, including mathematical models, applicable to the study of Hox and/or TALE gene function.
Dr. Vincenzo Zappavigna
Guest Editor
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Keywords
- HOX genes
- TALE homeodomain genes
- developmental biology
- transcriptional regulation
- post-transctiptional regulation
- epigenetic regulatory mechanisms
- evo–devo
- cancer biology
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