Special Issue "Poultry Genetics and Genomics"
Deadline for manuscript submissions: 20 February 2024 | Viewed by 8184
Interests: poultry; genetics and breeding; gene function; epigenetics; molecular-marker-assisted breeding; adipogenesis
Poultry meat and eggs are among the most common animal sources of food consumed at the global level. With continuous genetic selection, modern poultry has become the most efficient domestic animal, producing cheap and high-quality protein. The rapid development of poultry genetics and genomics breeding has brought huge economic benefits to the global poultry industry. However, numerous problems in poultry genetics and genomics remain to be addressed. For example, the complex genetic basis of important economic traits is still poorly understood, and the functional genes responsible for target traits require further mining. Genomic selection technology is immature, and its application in poultry breeding is still relatively limited.
This Special Issue aims to collect high-quality original research articles and comprehensive reviews to address emerging challenges in poultry genetics and genomics. Topics welcomed include, but are not limited to, genetic diversity and evolution, genome annotation, function and molecular mechanisms, omics studies, genomic selection, gene editing, and other new progress related to poultry genetics and genomics.
Dr. Tao Zhang
Dr. Genxi Zhang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- gene function
- genome annotation
- gene editing
- genomic selection
- molecular mechanisms
- molecular markers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Title: Integrative ChIP-seq and RNA-seq analysis reveals universal antiviral mechanism of chicken p53
Abstract: The tumor suppressor p53, which acts primarily as a transcription factor, has been shown to have antiviral functions against many viruses, such as infectious bursal disease virus (IBDV), avian leukosis virus subgroup J (ALV-J), and avian infectious laryngotracheitis virus (ILTV), in chickens. However, whether there is any universal antiviral mechanism of chicken p53 (chp53) remains unclear. In the present study, a comprehensive comparison of the molecular networks conferring the antiviral function of chp53 against IBDV, ALV-J, and ILTV was performed by a joint analysis of ChIP-seq data and RNA-seq data from chickens infected with these viruses. The enrichment of chp53 target genes in metabolic pathways was commonly observed and validated by ChIP-qPCR, suggesting a universal regulation of the metabolism of infected cells by chp53 upon the infection by different viruses. The present study provides new insights into the antiviral function of chicken p53 and indicates that targeting virus-host metabolic interaction could be a universal strategy for antiviral therapies in chickens.
2. Title: Unveiling the Molecular Mechanisms of Muscle Development During Late Embryonic Period in Broiler
3. Title: Molecular regulation of differential lipid molecule accumulation in intramuscular fat and abdominal fat of chicken
Abstract: Reducing abdominal fat (AF) accumulation and increasing the level of intramuscular fat (IMF) simultaneously is a major breeding goal in poultry industry. To explore the different molecular mechanisms between AF and IMF, gene expression profiles in the breast muscle (BM) and AF among three chicken breeds were analyzed. A total of 4737 shared DEGs were identified between BM and AF, of which 2602 DEGs were upregulated and 2135 DEGs were downregulated in the BM groups compared with that in AF groups. DEGs involved in glycerophospholipid metabolism and glycerolipid metabolism were potential regulators resulting in the difference of lipid metabolite accumulation in IMF and AF. PPAR signaling pathway was the most important pathway involved in tissue-specific lipid deposition. Correlation analysis showed that most representative DEGs enriched in PPAR signaling pathway, such as FABP5, PPARG, ACOX1, GK2, were negatively correlated with PUFA-enriched glycerophospholipid molecules. Most DEGs related to glycerophospholipid metabolism, such as GPD2, GPD1, PEMT, CRLS1 and GBGT1, were positively correlated with glycerophospholipid molecules, especially DHA- and arachidonic acid (ARA)- containing glycerophospholipid molecules. This study elucidated the molecular mechanism of tissue-specific lipid deposition and poultry meat quality.