Genomic Fabric Remodeling in Neurological Disorders

Dear Colleagues,

Hundreds of millions of people worldwide live with disorders affecting the brain, spinal cord, and peripheral nerves. Although neurological disorders have been intensively studied in humans and animal models, their underlying gene expression patterns (the transcriptomes) are still not fully understood. It has now become clear that the transcriptome is a multidimensional system composed of interacting, partially overlapping genomic fabrics, in which organizational principles are race/strain-, sex-, and age-dependent and can be altered by strong external stimuli.

In this Special Issue, we define the organizational feature of genomic fabrics and their interplay in specialized cells and regions of the nervous system. We aim to provide the reader with updated experimental and theoretical methods to explore, analyze, and interpret gene expression data resulting from RNA sequencing and microarray studies. Contributing papers will present quantification of the genomic fabrics remodeling in several severe neurological diseases and restoration following targeted therapies.

Dr. Dumitru A. Iacobas
Dr. David C. Spray
Guest Editors

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