DNA Damage and Repair at the Crossroad with Telomeres
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (5 November 2023) | Viewed by 21093
Special Issue Editor
2. Université Paris-Saclay, INSERM, CEA, Stabilité Génétique Cellules Souches et Radiations, F-92260 Fontenay-aux-Roses, France
Interests: telomere; nuclear envelope; lamins; senescence; DNA damage response; chromosome stability
Special Issue Information
Dear Colleagues,
Telomeres, which constitute the very ends of linear chromosomes, are essential for preserving genome stability in a wide range of eukaryotic organisms. Telomeres are capped by a specific telomere multiprotein complex that plays a key role in stabilizing and protecting chromosomes from degradation and recombination. In addition, over the past several years, several additional factors have been identified as being involved in telomere maintenance, including proteins from DNA damage signaling, repair and replication pathways. Some aspects of these mechanisms of telomere maintenance have been conserved throughout evolution. Telomere maintenance is crucial for cell growth and survival. Dysfunctional telomeres induce a DNA-damage-like response leading to cell-cycle arrest, genomic instability, senescence or cell death. Importantly, the deregulation of telomere maintenance has been linked to cancer genesis and premature aging. Furthermore, telomeric DNA, due to its highly G-rich content, is highly sensitive to oxidative stress and is vulnerable to different injuries, such as the unwanted formation of G-quadruplexes. Thus, a better understanding of mechanisms which could lead to DNA damage at telomeres, and in turn the identification of additional actors involved in their repair to avoid genome instability, are essential. In this view, telomere dynamics and their interplay with the nuclear envelope have brought new insight into the mechanisms of telomere maintenance.
In this Special Issue we aim to collect original research articles or reviews related to the DNA damage and repair at telomeres that contribute to bringing new highlights and novel findings. We especially welcome studies on a wide variety of eukaryotes, from yeasts to humans (including Arabidopsis and Drosophila), and those with a special focus on the dynamics of telomeres and their links with the nuclear envelope.
We look forward to receiving your contributions.
Dr. Gaëlle Pennarun
Guest Editor
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Keywords
- telomeres
- DNA repair
- DNA damage response
- genome instability
- senescence
- nuclear envelope
- evolution
- cancer
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