Special Issue "From Basic to Translational Bioinformatics of Human Infectious Diseases"
Deadline for manuscript submissions: 20 October 2022 | Viewed by 4546
In recent years, biomedical research with translational potential gradually changed from the investigation of limited sets of biological elements to a broader, more general, and complete perspective. The vital factors in this transition were remarkable technological developments in sequencing and related technologies, sample preparation methods, and bioinformatics tools. The ongoing revolution in this area enabled multiomics approaches, the sequencing of nucleic acids at single-cell resolutions, among others. In parallel, the potential for the use of publicly available “omics” datasets in integrative large-scale analysis is ever-increasing. Collectively, this raises the possibility of undertaking research, considering near full complexity of biological systems, that can be translated into advanced diagnostics, medical procedures, and therapies.
In this Special Issue of Genes, we invite you to send your contributions concerning any aspects related to the use of genomics, transcriptomics, proteomics, metabolomics, or other “omics” in fundamental or applied human infectious diseases studies. Submissions may range from genetic to metabolic and evolutionary aspects of host–pathogen interactions, including transcriptomic, genetic or epigenetic changes related to immune system responses or antimicrobial resistance in major, emerging or neglected human infectious diseases.
Dr. Nuno S. Osório
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- infectious diseases
- host–pathogen interaction
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
COVID-19 and statins
Coronavirus disease 2019 (COVID-19) is a disease caused by a new coronavirus SARS-CoV-2, which has recently affected the whole world. The course of the disease varies from asymptomat-ic to a very severe course even ending in the patient's death. The severe course is more common in people suffering from obesity, diabetes, lung diseases, cardiovascular diseases, or high blood pressure. Statins are currently the most widely used drugs for the treatment of hypercholester-olemia and the prevention of cardiovascular diseases. Therefore, here, we bring a study in which we have analyzed the effect of statins on the expression of genes, the variants of which are asso-ciated with a complicated course of COVID-19. Among such genes, there belong APOE and ACE2, i.e., genes encoding proteins involved in the innate antiviral immunity such as chemo-kines and their receptors (for example, CCR9, CXCR6, XCR1), or Toll-like receptors. The APOE gene encodes apolipoprotein E, which is involved in cholesterol transport, inflammatory re-sponse, and other immune responses. The latter, ACE2, encodes angiotensin-converting en-zyme 2, which serves as a membrane receptor for coronaviruses (including SARS-CoV-2) entry to host cells. In this study, as an experimental model for the statin study, adipose tissue-derived stem cells and pancreatic cancer cells cultured in vitro were used.