Genetic Variation in Age-Related Changes

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 1015

Special Issue Editor


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Guest Editor
Department of Biological Sciences, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
Interests: age-related changes; aging; genetic; Drosophila

Special Issue Information

Dear Colleagues,

In recent decades, researchers have devoted themselves to investigating the molecular mechanisms of aging and age-related diseases, which is crucial for identifying strategies that facilitate healthy aging. Genomics and multi-omics approaches have significantly advanced biomedical research, providing the research community with unprecedented quantities of data. Despite the fact that we have gained more knowledge about the aging process and the pathways of disease susceptibility, there is significant variation among individuals with regard to their rate of aging and disease susceptibility. This variation has a genetic component, but we have an incomplete understanding of the genetic basis of this variation, particularly concerning genes that control the age-specific changes in traits that contribute to senescence and ultimately limit life span.

This Special Issue, entitled “Genetic Variation in Age-Related Changes”, aims to provide a comprehensive overview of the most recent advances in this timely topic and a preview of future research directions and challenges.

Prof. Dr. Jeff Leips
Guest Editor

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Keywords

  • aging
  • age-related change
  • age-related complex traits
  • genetic variation
  • health

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Published Papers (1 paper)

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Research

12 pages, 1116 KiB  
Article
Metallothionein-1A (MT1A) Gene Variability May Play a Role in Female Frailty: A Preliminary Study
by Paolina Crocco, Francesco De Rango, Rossella La Grotta, Giuseppe Passarino, Giuseppina Rose and Serena Dato
Genes 2025, 16(1), 15; https://doi.org/10.3390/genes16010015 - 26 Dec 2024
Viewed by 756
Abstract
Background/Objectives: Frailty is a complex geriatric syndrome resulting in decreased physiological reserve. While genetics plays a role, the underlying mechanisms remain unsolved. Metallothioneins (MTs), metal-binding proteins with high affinity for zinc, an essential mineral for many physiological functions, are involved in processes including [...] Read more.
Background/Objectives: Frailty is a complex geriatric syndrome resulting in decreased physiological reserve. While genetics plays a role, the underlying mechanisms remain unsolved. Metallothioneins (MTs), metal-binding proteins with high affinity for zinc, an essential mineral for many physiological functions, are involved in processes including oxidative stress and inflammation. We investigated the impact of genetic variations in MTs on frailty. Methods: 448 subjects (235 females and 213 males, median age of 76 years) were categorized into three frailty groups (non-frail/pre-frail/frail), by hierarchical cluster analysis based on cognitive status (MMSE), functional capacity (ADL), and physical strength (HGS). Subjects were analyzed for selected SNPs in MT1A, MT1B, MT2A, and MT3 genes by PCR-RFLP. Results: An association was found between the rs8052394-A/G (Lys51Arg) polymorphism in the MT1A gene and frailty in females both in binary (OR = 0.345, p = 0.037) and multinomial logistic regression (OR = 0.343, p = 0.036) corrected for age and sex, with carriers of the minor G-allele less likely to transition from non-frail to pre-frail status. Additionally, a significant association with albumin levels (beta = 0.231; p = 0.027) and a trend of association with CRP levels (beta = −1.563; p = 0.097) were observed for this SNP in non-frail females, both indicative of a low inflammatory status. However, Bonferroni correction for multiple SNPs and physiological parameters tested renders these results statistically non-significant. Conclusions: Although its associations do not survive Bonferroni correction, this exploratory study suggests a sex-specific influence of MT1A variability in frailty, likely affecting zinc availability, aligning with ongoing research on sex differences in frailty risk and progression. Larger studies are needed to validate these findings and clarify the mechanisms behind MTs’ variability in frailty progression. Full article
(This article belongs to the Special Issue Genetic Variation in Age-Related Changes)
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