Protein Synthesis in Cancer Initiation, Progression, Metastasis, and Dormancy
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (25 January 2025) | Viewed by 1565
Special Issue Editor
2. School of Medicine and Health Sciences, Tecnológico de Monterrey, Mexico City 14380, Mexico
Interests: developmental biology; molecular biology; cancer
Special Issue Information
Dear Colleagues,
Cancer is one of the most prevalent diseases worldwide. Despite the advances in the understanding of the molecular processes driving the onset and progression of this disease, cancer still remains a significant cause of morbidity and mortality, particular in low-income countries. Translation, i.e., the decoding of a genetic message carried by a messenger (m)RNA into a polypeptide by the ribosome and translation factors, plays a crucial role in the composition of the proteome in all forms of life and diseases. Dysregulation of the translation process has emerged as a crucial cause of tumorigenesis. Indeed, various translation factors include oncogenes, while others are overexpressed in tumors, and some components of the translational machinery are mutated across different types of neoplastic phenotypes. Moreover, malfunctioning of the signal transduction cascades controlling translation are also involved in the onset and progression of cancer. Thus, the targeting of translation initiation is investigated as part of the global applications in some emerging therapies used to treat carcinogenesis.
We dedicate this Special Issue to discuss the state of the art of key aspects of protein synthesis in cancer initiation, progression, metastasis, and dormancy. This includes the misexpression of translation factors, dysregulation of the major signaling cascades regulating translation, and therapeutic strategies based on pharmacological compounds targeting translation.
Dr. Greco Hernández
Guest Editor
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Keywords
- cancer
- translational control
- protein synthesis
- mTOR pathway
- cancer therapeutics
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