Colorectal Cancer Screening (CRC) in the EU

A special issue of Gastrointestinal Disorders (ISSN 2624-5647).

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1121

Special Issue Editors


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Guest Editor
Family Medicine and Population Health (FAMPOP), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium
Interests: cancer screening; preventive medicine

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Guest Editor
Family Medicine and Population Health, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
Interests: cancer screening; health behaviour; prevention
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Special Issue Information

Dear Colleagues,

We invite you to submit a manuscript to the Special Issue of Gastrointestinal Disorders on ‘Colorectal Cancer Screening (CRC) in the EU’. Possible topics are adherence to EU guidelines, strengths and limitations of current CRC screening strategies, benefits and risks of specific screening strategies, similarities and differences in CRC screening among EU countries, determinants of (non)participation, good practices of decreasing inequality in CRC screening and improving uptake of CRC screening in the target population, especially vulnerable groups.

Dr. Sarah Hoeck
Prof. Dr. Guido Van Hal
Guest Editors

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Keywords

  • colorectal cancer
  • screening
  • prevention
  • colonoscopy
  • qualitative research
  • quantitative research
  • EU guidelines
  • participation
  • inequality

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Published Papers (1 paper)

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Research

14 pages, 2767 KiB  
Article
Reliability of Kudo’s Glandular Pit Pattern in Predicting Colorectal Lesion Histology at Routine Colonoscopy with Digital Chromoendoscopy
by Sabrina Gloria Giulia Testoni, Pier Alberto Testoni, Chiara Notaristefano, Edi Viale and Giulia Martina Cavestro
Gastrointest. Disord. 2024, 6(3), 661-674; https://doi.org/10.3390/gidisord6030044 - 10 Jul 2024
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Abstract
Background. The large number of lesions detected via high-definition (HD) imaging during colonoscopy calls for the reliable real-time histological characterization of polyps, especially diminutive and small ones, to permit tailored management based on the neoplastic risk, such as a “resect-and-discard” or a [...] Read more.
Background. The large number of lesions detected via high-definition (HD) imaging during colonoscopy calls for the reliable real-time histological characterization of polyps, especially diminutive and small ones, to permit tailored management based on the neoplastic risk, such as a “resect-and-discard” or a “diagnose-and-leave” strategy for low-risk adenomas and hyperplastic polyps (HPs). The Kudo classification of glandular pit pattern is currently used for predicting polyp histology. Aim. The aim in this study was to assess whether Kudo’s glandular pit pattern, assessed via HD digital chromoendoscopy (i-Scan) without magnification and optical enhancement, reliably predicts polyp histology and differentiates neoplastic lesions (NLs) from non-neoplastic lesions (non-NLs) during routine colonoscopy. Methods. Consecutive colorectal lesions recorded in a database over 12 months, with Kudo’s glandular pit pattern classification, were retrospectively compared with histology. The diagnostic accuracy and negative predictive value (NPV) for adenomatous histology of Kudo’s pit patterns were assessed separately for diminutive (≤5 mm) and small (6–9 mm) polyps, accordingly to the American Society for Gastrointestinal Endoscopy (ASGE) Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI), and in large (≥10 mm) lesions. Results. A total of 2230 lesions were recorded: 898 diminutive, 704 small, and 628 large. Kudo’s type II pit pattern was prevalent in diminutive polyps and recognized mostly in HPs (83.27%); it was also found in 38.8% of adenomas. In the right colon, Kudo’s type II pit pattern was prevalent in adenomas (70.04% vs. 20.74% in HPs); among the serrated lesions, it was evenly distributed between HPs and adenomas. Kudo’s type IIIL/IIIs/IV pit pattern was prevalent in NLs (61% vs. 8.37% of non-NLs) in diminutive polyps, evenly distributed between non-NLs and NLs in small polyps, and found only in NLs in large polyps. Kudo’s type Vi/Vn pit pattern correctly identified all but one adenocarcinoma. The NPV for adenomatous histology did not reach the recommended 90% PIVI threshold for differentiation between NLs and non-NLs in diminutive polyps showing Kudo’s type II pit pattern and in small polyps showing type IIIL/IIIs/IV pit pattern. Conclusions. Kudo’s pit pattern classification carried out with digital chromoendoscopy (i-Scan) during routine colonoscopy does not allow the reliable differentiation between non-NLs and NLs in diminutive and small polyps, so a “diagnose-and-leave” strategy for diminutive polyps may leave undetected adenomas, while a “resect-and-discard” strategy could miss lesions requiring closer follow-up. Full article
(This article belongs to the Special Issue Colorectal Cancer Screening (CRC) in the EU)
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