Isolation and Extraction of Bioactive Peptides from Food and Food By-Products
A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Biotechnology".
Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 988
Special Issue Editor
Special Issue Information
Dear Colleagues,
The isolation and extraction of bioactive peptides (BAPs) from food and food by-products have garnered significant interest, as they serve as a critical step to unlock the potential of BAPs—with diverse physiological functions (e.g., antioxidation, antihypertensive, immunomodulatory). The commonly used and preferred method for BAPs generation is enzymatic hydrolysis and microbial fermentation. Novel technologies such as high hydrostatic pressure, ultrasonic-assisted extraction, microwave-assisted extraction, pulsed electric fields, and ohmic heating have been developed to modify the degree of hydrolysis, thereby improving BAPs’ yield. After hydrolysis, fractionation and purification can be performed using membrane filtration, chromatography, or their combinations. Despite BAPs’ potential, challenges persist, including limited bioavailability, poor stability, and insufficient understanding of the structure–activity relationships. Recent advancements in extraction, purification, and identification techniques, combined with machine learning (ML)-based bioactivity prediction and AI-driven structure modelling, have broadened research perspectives and opened new avenues for BAPs research. The isolation and extraction of BAPs hold broad application prospects in the food and nutraceutical industries, driving the development of high-value functional products, sustainable food systems, and emerging research directions such as gut microbiome interactions and personalized nutrition.
Prof. Dr. Yuxing Guo
Guest Editor
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Keywords
- bioactive peptides (BAPs)
- physiological function
- enzymatic hydrolysis
- microbial fermentation
- membrane filtration
- chromatography
- bio-availability
- structure-activity relationships
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