Functional Ingredients in Foods: Physicochemical Properties, Delivery System and Health Benefits

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Physics and (Bio)Chemistry".

Deadline for manuscript submissions: 10 April 2026 | Viewed by 623

Special Issue Editors


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Guest Editor
Ningbo Cixi Institute of Biomedical Engineering, Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Interests: food chemistry; phytochemistry; bioanalytical chemistry; bioactive compounds; LC-MS-based omics; nanomaterials and nanomedicines
Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China
Interests: screening of natural bioactive compounds; construction of nano-delivery systems

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Guest Editor
Hebei Key Laboratory of Public Health Safety, School of Public Health, Hebei University, Baoding 071002, China
Interests: phytonutrients; new analytical methods; target-based recognition; metabolomics; biological activity
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Special Issue Information

Dear Colleagues,

The growing demand for healthier, value-added foods has accelerated research into functional ingredients with bioactive properties that extend beyond basic nutrition. This Special Issue highlights recent advances in understanding the biological and physicochemical properties of functional compounds in foods from their targets guided screening/identification strategies to better improvement in their stability and bioavailability. Special attention is also given to innovative delivery systems such as nanoencapsulation, emulsions, hydrogels, etc., which enhance solubility, protect against degradation, enable the targeted release of bioactive ingredients in the gastrointestinal tract, and showcase advanced encapsulation and targeted release technologies designed to enhance stability and efficacy.

In addition, the contributions examine how functional ingredients contribute to disease prevention and health promotion, focusing on benefits such as antioxidant activity, anti-inflammatory effects, gut microbiota modulation, and metabolic regulation.

By covering food chemistry, material science, biological chemistry, and nutrition, this collection provides a comprehensive overview of some updated new strategies driving the development of next-generation functional foods and advancing food innovation that meets both scientific and consumer expectations for better health, safety, and sustainability. We invite contributions that provide novel insights into the development, application, and mechanistic actions of functional ingredients, fostering a deeper understanding of their potential in future food design and human wellness.

Prof. Dr. Mingquan Guo
Dr. Mengjia Xu 
Dr. Zhiqiang Wang
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional foods
  • bioactive compounds
  • physicochemical properties
  • delivery systems
  • bioavailability
  • bio-accessibility
  • health benefits

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Published Papers (1 paper)

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Research

27 pages, 5977 KB  
Article
Multi-Target Screening of Anti-Diabetic and Antioxidant Potential Bioactive Constituents from Dandelion
by Xiaocui Zhuang, Yang Xu, Yuanqing Zhou, Dongbao Hu, Minxia Fan, Xinyi Cui, Mingyang Luo, Ya Shu, Li Wang, Yahong Fei, Wei Shi and Mingquan Guo
Foods 2025, 14(23), 3990; https://doi.org/10.3390/foods14233990 - 21 Nov 2025
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Abstract
Taraxacum mongolicum Hand.-Mazz (TMHM), a primary source of dandelion, is a globally recognized edible and medicinal plant with significant potential in food, medicine, daily chemical products, and animal husbandry. Although hypoglycemic effects have been reported in other Taraxacum species, the specific hypoglycemic constituents [...] Read more.
Taraxacum mongolicum Hand.-Mazz (TMHM), a primary source of dandelion, is a globally recognized edible and medicinal plant with significant potential in food, medicine, daily chemical products, and animal husbandry. Although hypoglycemic effects have been reported in other Taraxacum species, the specific hypoglycemic constituents and mechanisms of TMHM are not well understood. The absence of comprehensive multi-target screening methodologies has hindered the elucidation of TMHM’s dual inhibitory effects on α-amylase and α-glucosidase, as well as its associated molecular mechanisms. In this study, a multi-target screening strategy was developed to concurrently evaluate α-amylase and α-glucosidase inhibition, integrating multi-target affinity ultrafiltration coupled with ultra-performance liquid chromatography-tandem mass spectrometry (MTAUF-UPLC-MS/MS), molecular docking, and molecular dynamics (MD) simulations. Using this approach, 13 dual-target inhibitors were identified from TMHM. Moreover, at least 5 of these compounds exhibited anti-diabetic activities comparable to the positive control drug acarbose, suggesting that they are principal bioactive constituents responsible for its hypoglycemic effects. Subsequent investigation of the antioxidant capacities of 7 out of the 13 bioactive compounds revealed that most exhibited more potent antioxidant activities than vitamin C (Vc). Based on these findings, molecular docking and MD simulations further validated that quercetin (8) and kaempferol (15), which demonstrated significant hypoglycemic and antioxidant activities, exhibited particularly strong affinities and stable interactions with α-amylase and α-glucosidase, respectively. In conclusion, these findings underscored the considerable potential of TMHM as a natural source of multifunctional bioactive compounds for nutraceutical, functional, and pharmaceutical applications. This study provided a critical foundation for elucidating the mechanisms underlying TMHM’s anti-diabetic effects and its therapeutic potential in mitigating diabetes-related complications, thereby facilitating future development and utilization. Full article
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