Environmental Chemical Exposure and Human Health

A special issue of Environments (ISSN 2076-3298).

Deadline for manuscript submissions: 25 July 2026 | Viewed by 1290

Special Issue Editors


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Guest Editor
College of Environmental Sciences and Engineering, Peking University, Beijing, China
Interests: environmental chemical exposure; endocrine-disrupting chemicals; transgenerational health impact; risk mitigation strategies; life-course epidemiology; environmental epidemiology

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Guest Editor
Disaster Preparedness and Emergency Management, University of Hawaii, 2540 Dole Street, Honolulu, HI 96822, USA
Interests: epidemiology and prevention of congenital anomalies; psychosis and affective psychosis; cancer epidemiology and prevention; molecular and human genome epidemiology; evidence synthesis related to public health and health services research
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Civil & Environmental Engineering, Universita degli Studi di Perugia, 06123 Perugia, Italy
Interests: dynamics of elementary chemical processes (combustion and atmospheric chemistry); production and characterization of excited and ionic species relevant in planetary ionospheres and astrochemistry; double photoionization of chiral molecules; photo-degradation mechanisms of biomolecules exposed to ionizing radiation; photocatalytic efficiency of TiO2 powders in the degradation of atmospheric pollutants species; analytical and environmental chemistry; environmental radioactivity; green fuels production by carbon dioxide hydrogenation reaction with and without solid phase catalysis; chemical characterization of officinal plants and fruits (nutritional and pharmacological properties)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue on “Environmental Chemical Exposure and Human Health.”

Environmental chemicals, from industrial pollutants to endocrine disrupting chemicals, pose significant risks to human health, particularly during critical windows of development and across generations. The World Health Organization (WHO) emphasizes that nearly 24% of global deaths are linked to environmental factors, with early-life exposures influencing lifelong health trajectories. This Special Issue seeks to advance understanding of how chemical exposure impacts health, from preconception through adulthood, while exploring innovative strategies to mitigate risks and elucidate biological mechanisms.

Mounting scientific evidence demonstrates that environmental chemical exposures contribute substantially to adverse birth outcomes, developmental impairments, and multi-generational health effects through epigenetic mechanisms. Concurrently, breakthroughs in exposome science and multi-omics approaches (including epigenomics, metabolomics, and proteomics) are revealing previously unknown exposure-disease pathways. The integration of these mechanistic insights with population-level prevention strategies represents a critical opportunity to mitigate the worldwide impact of environmentally mediated diseases across the lifespan.

This Special Issue will feature research on the following topics:

  • Life-course chemical exposure and health outcomes;
  • Transgenerational effects of chemical exposure;
  • Mitigation measures targeting modifiable factors, such as behavioral factors;
  • Exposome and omics approaches to identify biomarkers and mechanistic pathways;
  • Molecular mechanisms of toxicity.

We invite original research, systematic reviews, and methodological papers that address these themes, with a focus on interdisciplinary collaboration among environmental health, toxicology, epidemiology, and public health.

Dr. Yu Zhang
Prof. Dr. Jason Levy
Prof. Dr. Stefano Falcinelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Environments is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental chemical exposure
  • endocrine-disrupting chemicals
  • transgenerational health impact
  • risk mitigation strategies
  • life-course epidemiology
  • environmental epidemiology
  • developmental origins of health and disease (DOHaD)
  • exposome
  • multi-omics technologies
  • epigenetic inheritance

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Published Papers (1 paper)

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Research

22 pages, 2418 KB  
Article
Environmental Mercury Exposure in Residents and Occupational Groups of Coastal Areas of the Marano and Grado Lagoon (Northern Adriatic Sea, Italy)
by Luca Cegolon, Emilia Patriarca, Elisa Petranich, Giuseppe Mastrangelo, Francesca Larese Filon, Donatella Sansone and Stefano Covelli
Environments 2026, 13(3), 159; https://doi.org/10.3390/environments13030159 - 13 Mar 2026
Viewed by 824
Abstract
The Marano and Grado lagoon (Northern Adriatic Sea, Italy) has been affected by long-standing mercury (Hg) pollution due to inputs from the Isonzo River—mainly in the form of cinnabar (HgS)—and inorganic Hg conveyed into the lagoon by discharges from the chlor-alkali plant of [...] Read more.
The Marano and Grado lagoon (Northern Adriatic Sea, Italy) has been affected by long-standing mercury (Hg) pollution due to inputs from the Isonzo River—mainly in the form of cinnabar (HgS)—and inorganic Hg conveyed into the lagoon by discharges from the chlor-alkali plant of Torviscosa. The present study compared different occupational sub-groups along the Marano and Grado lagoon against residents of the Dolomites Alps. Seventy-three local fishermen, 81 workers of the fish industry, and 76 local workers (52 employees of a large adhesive factory and 24 workers of an oil mill) of Porto Nogaro were recruited by convenience sampling. Hair mercury levels of the latter three groups were compared with those of 93 residents of the Dolomites Alps. Linear and logistic regression analyses were used to assess the association of hair mercury with various factors collected by a structured questionnaire. Median hair Hg levels were significantly lower in Dolomites’ residents (0.58 mg/Kg) compared to Porto Nogaro workers (1.31 mg/Kg), workers of the fish industry (2.32 mg/Kg) or fishermen (2.56 mg/Kg), following an upward trend. After adjusting for a number of potential confounders, the concentration of hair Hg progressively increased with fish intake at linear and logistic regression analysis. Advising to limit the consumption of locally caught fish to no more than one meal per week should not be restricted to pregnant women and children, but should also be extended to adults, in order to avoid the potential long-term neurological effects of low-dose Hg exposure. It is crucial to remain vigilant and continue monitoring Hg environmental contamination in the lagoon across various environmental matrices, such as sediments, water, fish, shellfish and birds. Regardless of Hg levels measured in the workplace, occupational health protocols of steel plants along the coastal area of the Marano and Grado lagoon should include biological monitoring of Hg, to disentangle the effect of occupational exposure from non-occupational exposure to the metal. Full article
(This article belongs to the Special Issue Environmental Chemical Exposure and Human Health)
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