Advanced Neuroimaging Analysis: From Data to Diagnosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2982

Special Issue Editor


E-Mail Website
Guest Editor
Faculty of Physical Chemistry, University of Belgrade, 11000 Belgrade, Serbia
Interests: magnetic resonance imaging; machine learning; multimodal neuroimaging data fusion; biomarker discovery; precision medicine; predictive modeling; AI in neuroimaging

Special Issue Information

Dear Colleagues,

The Special Issue entitled “Advanced Neuroimaging Analysis: From Data to Diagnosis” explores the transformative role of advanced and multimodal neuroimaging and sophisticated analytical pipelines in bridging the gap between complex neuroimaging data and accurate clinical diagnosis. Furthermore, this Collection aims to highlight studies that move beyond descriptive imaging, seeking instead to extract actionable biomarkers that inform diagnosis, prognosis, and personalized treatment strategies.

Particular focus is placed on the following:

  • Integrative analysis of multimodal MRI, PET, EEG-fMRI or MRSI;
  • Development and validation of novel image processing methods and pipelines;
  • Identification of imaging-based biomarkers for neurological and psychiatric disorders;
  • Advanced neuroimaging research connecting imaging findings to clinical outcomes and therapeutic response.

Moreover, this Collection recognizes the importance of methodological transparency, reproducibility, and the ethical challenges of data-driven diagnostic tools. Contributors are encouraged to discuss limitations, standardization efforts, and strategies for responsible clinical implementation of advanced neuroimaging techniques.

This Collection welcomes the submission of original research articles, methodological papers, and comprehensive reviews.

Dr. Igor Petrušić
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroimaging analysis 
  • multimodal integration 
  • multimodal imaging 
  • biomarkers 
  • diagnostic pipelines 
  • clinical translation 
  • neurological disorders

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 2088 KB  
Article
Functional Magnetic Resonance Imaging for Investigating the Role of the Hippocampus in Migraine with Aura
by Mojsije Radović, Marko Daković, Aleksandra Radojičić and Igor Petrušić
Diagnostics 2026, 16(7), 1111; https://doi.org/10.3390/diagnostics16071111 - 7 Apr 2026
Viewed by 219
Abstract
Background/Objectives: Migraine with aura (MwA) is a heterogeneous disorder comprising pure visual aura (MwAv) and more complex phenotypes with additional somatosensory and/or dysphasic symptoms (MwAvsd). Previous structural magnetic resonance imaging (MRI) studies have demonstrated hippocampal subfield volume reductions associated with aura complexity, [...] Read more.
Background/Objectives: Migraine with aura (MwA) is a heterogeneous disorder comprising pure visual aura (MwAv) and more complex phenotypes with additional somatosensory and/or dysphasic symptoms (MwAvsd). Previous structural magnetic resonance imaging (MRI) studies have demonstrated hippocampal subfield volume reductions associated with aura complexity, suggesting a role for the hippocampus in MwA pathophysiology. However, functional network mechanisms underlying these structural differences remain unclear. This study aimed to investigate hippocampal resting-state functional connectivity (FC) in MwA subtypes and healthy controls (HCs), and to determine whether hippocampal connectivity patterns differ according to aura complexity. Methods: In this comparative cross-sectional study, 27 patients with MwAvsd, 18 with MwAv, and 29 age- and sex-matched HCs underwent resting-state functional MRI on a 3T scanner. Seed-based FC analyses were performed using both hippocampi as regions of interest. Results: MwAvsd patients demonstrated significantly increased FC between the right hippocampus and the left dorsal parietal cortex and right sensory association cortex compared with MwAv patients. In contrast, MwAv patients showed increased FC between the left hippocampus and the right dorsolateral prefrontal cortex compared with MwAvsd patients. Additionally, MwAv patients exhibited stronger FC between the left hippocampus and bilateral anterior prefrontal cortices and the left angular cortex compared with HCs. No other significant hippocampal FC differences were observed. Conclusions: Hippocampal FC is altered in MwA and varies according to aura phenotype. Complex aura is characterized by enhanced hippocampal coupling with multisensory integration regions and reduced connectivity with executive control areas, whereas pure visual aura demonstrates increased hippocampal–prefrontal and hippocampal–parietal associative connectivity compared with HCs. These findings suggest that the hippocampus might serve as a target for future neuromodulatory and therapeutic investigations in MwA patients. Full article
(This article belongs to the Special Issue Advanced Neuroimaging Analysis: From Data to Diagnosis)
Show Figures

Figure 1

Back to TopTop