Hepatocellular Carcinoma: Diagnosis and Management
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 56
Special Issue Editor
2. Department of Nursing, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
Interests: cancer genomics; transcriptomics; personalized medicine; cancer onset and development; cancer biomarkers; diagnostic strategies
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for ~90% of cases, and is the third leading cause of cancer-related deaths globally. While it has traditionally been diagnosed in its late stages, improved surveillance in patients with cirrhosis and advances in imaging have enabled earlier detection and curative treatment options. Major risk factors include chronic infection with hepatitis B and C viruses, as well as non-alcoholic steatohepatitis (NASH), which is increasingly common in the West and presents a distinct molecular pathogenesis. About 25% of HCCs carry potentially actionable mutations, though their clinical utility remains under investigation. Ultrasound is recommended for the surveillance and follow-up of nodules ≤1 cm, while contrast-enhanced CT or MRI is preferred for nodules >1 cm. Biopsies may be required for atypical lesions but are limited by sampling errors. Subcentimeter lesions should be monitored with repeat imaging and alpha-fetoprotein (AFP) testing every 3–6 months. Accurate diagnosis, proper staging, and timely treatment are vital for improving outcomes. Ongoing research in cancer biomarkers, genomics, transcriptomics, and personalized medicine continues to advance our understanding of HCC and refine diagnostic and therapeutic strategies.
Dr. Po-Ming Chen
Guest Editor
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Keywords
- hepatocellular carcinoma
- chronic infection
- non-alcoholic steatohepatitis
- diagnostic and therapeutic strategies
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