Applications of Optical Coherence Tomography in the Ocular Diagnosis: From the Tear Film to the Sclera 2.0

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 715

Editors


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Guest Editor
Multidisciplinary Department of Medical, Surgical and Dental Sciences, Università degli Studi della Campania ‘Luigi Vanvitelli’, Via Pansini 5, 80131 Naples, Italy
Interests: retina; OCT; degenerative macular diseases; OCT-A; retinal diagnostics; surgical retina
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Special Issue Information

Dear Colleagues,

The latest technological developments have radically impacted the daily practice of ophthalmologists thanks to the advent of novel diagnostic tools that facilitate an early diagnosis and provide a better management of ocular disorders. Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) have acquired key roles in developing a better understanding of the pathogenesis of several ocular conditions; moreover, they have remarkably changed the diagnostic approach to many ophthalmic and systemic diseases. This Special Issue aims to create a multidisciplinary forum of discussion about the clinical and research applications of these technologies (OCT and OCTA) in the ocular diagnosis of different subfields of ophthalmology. Innovative applications of optical coherence tomography in every ophthalmic field will be very welcome. Submissions are welcome primarily for high-quality original research articles showing new developments and innovative findings about these topics. Secondarily, we will consider high-interest review articles and case series of exceptional merit.

Dr. Claudio Iovino
Dr. Jay Chhablani
Prof. Dr. Giuseppe Giannaccare
Guest Editors

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Keywords

  • optical coherence tomography
  • optical coherence tomography angiography
  • corneal curvature
  • tear film
  • central corneal thickness
  • glaucoma
  • anterior chamber
  • iris angiography
  • macular thickness
  • choroidal thickness
  • axial length measurement
  • retinal vascular plexuses
  • choroidal vasculature
  • macular surgery

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Published Papers (1 paper)

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Review

14 pages, 3508 KB  
Review
Advanced Preoperative Imaging in Macula-Off Rhegmatogenous Retinal Detachment: Emerging Diagnostic and Prognostic Insights for Clinical Management
by Lorenzo Motta, Rodolfo Mastropasqua, Michele Cillis, Giulia Craighero, Nicola Sereni, Corina De Santis, Alberto Quarta, Aldo Gelso, Giuseppe Lo Giudice and Claudio Iovino
Diagnostics 2026, 16(11), 1581; https://doi.org/10.3390/diagnostics16111581 - 22 May 2026
Viewed by 367
Abstract
Retinal detachment (RD) is a potentially sight-threatening condition that requires timely diagnosis and appropriate surgical management. In macula-off rhegmatogenous retinal detachment (RRD), visual recovery after successful reattachment remains highly variable, highlighting the need for reliable preoperative prognostic markers. This study focuses on the [...] Read more.
Retinal detachment (RD) is a potentially sight-threatening condition that requires timely diagnosis and appropriate surgical management. In macula-off rhegmatogenous retinal detachment (RRD), visual recovery after successful reattachment remains highly variable, highlighting the need for reliable preoperative prognostic markers. This study focuses on the contribution of advanced retinal imaging to the preoperative assessment of macula-off RRD, summarizing current evidence on imaging-derived biomarkers associated with disease severity and postoperative functional outcome. In this narrative review, we analyze studies employing spectral-domain and swept-source optical coherence tomography (SD-OCT and SS-OCT), OCT angiography (OCT-A), and adaptive optics OCT (AO-OCT) to characterize microstructural and microvascular retinal alterations. Emerging approaches, including ultra-widefield OCT (UWF-OCT) and artificial intelligence-based image analysis, are also discussed for their potential role in refining diagnosis, supporting surgical planning, and improving prognostic stratification. While several imaging parameters appear promising, their prognostic value is not yet fully realized. Further prospective studies are required to validate clinically meaningful imaging biomarkers and to integrate advanced imaging into routine preoperative decision-making for macula-off RRD. Full article
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