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Diagnostics
Special Issues
New Trends in Mobility Medicine Diagnostics
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New Trends in Mobility Medicine Diagnostics

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 133

Special Issue Editor

Prof. Dr. Ugo Carraro

E-Mail Website
Guest Editor
School of Physical Medicine and Rehabilitation, Department of Neuroscience, University of Padova, Padua, Italy
Interests: genetic and acquired skeletal muscle disorders; mobility functional tests; skeletal muscle imaging; quantitative tissue densitometry by 3D and 2D color CT and MRI; blood and mouth fluid biomarkers; targeted management and follow-up in mobility medicine; functional electrical stimulation of denervated and reinnervating muscles; home full-body in-bed gym exercise; spa, thermal, and balneotherapy; hemi-fasting and other nutritional supplements of mobility medicine in aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For the past thirty-five years, Padua Muscle Days (Padua, Italy), an international conference, has offered multidisciplinary opportunities that have led to groundbreaking translational results, prompting the introduction of the term "mobility medicine". Mobility medicine is not yet officially recognized as an academic discipline, but it demonstrates the urgent need to bring together knowledge currently dispersed across subspecialties to finally address neuromuscular disorders and improve performance. The programs of recent Padua Muscle Days demonstrate that effective countermeasures can be organized to the inevitable tendencies toward hyper specialization that exponential growth in scientific progress brings. We are confident that this Special Issue, "New Trends in Mobility Medicine Diagnostics", (NTiMMD) in the MDPI (Basel) journal Diagnostics will significantly contribute to making "mobility medicine" a recognized neologism, as diagnosis is essential to preventing, managing, and monitoring not only neurometabolic-muscle disorders but also the inevitable decline in performance in early and late aging. We look forward to numerous contributions, hoping that many other researchers, both young and senior, will share our goal.

Prof. Dr. Ugo Carraro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mobility medicine
  • genetic and acquired neuromuscular disorders
  • mobility medicine of aging
  • mobility functional tests
  • skeletal muscle and cartilage imaging
  • quantitative tissue densitometry by 3D and 2D color CT and MRI
  • blood and mouth fluid biomarkers in mobility medicine
  • management and follow-up in mobility medicine
  • functional electrical stimulation of permanently denervated and reinnervating muscles

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Published Papers (1 paper)

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19 pages, 1519 KB  
Review
Pathophysiological, Translational, and Diagnostic Aspects of ME/CFS: A Focus on Skeletal Muscle Involvement
by Giorgio Fanò-Illic, Francesco Coscia, Paola V. Gigliotti, Franco Checcaglini, Ugo Carraro, Stefania Fulle and Rosa Mancinelli
Diagnostics 2026, 16(7), 1019; https://doi.org/10.3390/diagnostics16071019 (registering DOI) - 28 Mar 2026
Abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multisystemic disorder characterized by severe, persistent fatigue not alleviated by rest and worsened by minimal exertion, often accompanied by post-exertional malaise (PEM), unrefreshing sleep, cognitive dysfunction, and autonomic disturbances. Despite decades of research, its pathophysiology [...] Read more.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multisystemic disorder characterized by severe, persistent fatigue not alleviated by rest and worsened by minimal exertion, often accompanied by post-exertional malaise (PEM), unrefreshing sleep, cognitive dysfunction, and autonomic disturbances. Despite decades of research, its pathophysiology remains incompletely understood, and skeletal muscle involvement has only recently gained attention. This review aims to provide a historical and pathophysiological synthesis of ME/CFS, emphasizing the pivotal role of skeletal muscle in the onset and persistence of symptoms, and to integrate molecular, cellular, and pathophysiological evidence into a coherent explanatory framework. This is a narrative review of published literature (1990–2025) with critical integration of clinical, biochemical, and experimental data on oxidative stress, mitochondrial dysfunction, Excitation–Contraction (E-C coupling) dysregulation, and muscle secretome alterations in ME/CFS also in relation to post-viral syndromes (e.g., Long COVID). Evidence consistently points to mitochondrial oxidative stress, redox imbalance, impaired Ca2+ handling, and altered signaling pathways in skeletal muscle of patients with ME/CFS. Historical milestones show an evolution from psychogenic interpretations toward recognition of ME/CFS as a biological disorder with neuromuscular and metabolic underpinnings. ME/CFS can be interpreted as a skeletal muscle–metabolic disorder characterized by oxidative distress, mitochondrial dysfunction, and impaired energy regulation, leading to the clinical picture of exercise intolerance and post-exertional malaise. Integrating basic and clinical research through a translational approach provides the foundation for new diagnostic tools, targeted therapies, and biomarkers. Full article
(This article belongs to the Special Issue New Trends in Mobility Medicine Diagnostics)
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