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Diagnostics
Special Issues
Emergency Medicine: Diagnostic Insights
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Emergency Medicine: Diagnostic Insights

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 76

Special Issue Editors

Dr. Ancor Sanz-Garcia

E-Mail Website
Guest Editor
Faculty of Health Sciences, Universidad de Castilla la Mancha, Talavera de la Reina, Castilla-La Mancha, Spain
Interests: prehospital; emergency medicine; risk scores; biomarkers; emergency medical services
Special Issues, Collections and Topics in MDPI journals
Dr. Raúl López-Izquierdo

E-Mail Website
Guest Editor
Emergency Department, Hospital Universitario Rio Hortega, Valladolid, Spain
Interests: biomarkers; early warning scores; emergency medicine; risk scores; sepsis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will provide a comprehensive exploration of the latest advancements and challenges in diagnostic techniques within the field of emergency medicine. It will highlight the critical role of rapid and accurate diagnosis in ensuring prompt and effective patient care in emergency settings. This Special Issue will feature in-depth articles on innovative diagnostic tools and technologies, including imaging modalities, biomarkers, and AI-driven algorithms, which are transforming the diagnostic landscape of emergency medicine. Furthermore, we will present case studies and expert opinions on diagnostic strategies tailored to specific emergency conditions, providing valuable insights for healthcare professionals striving to improve patient outcomes in emergency care.

Dr. Ancor Sanz-Garcia
Dr. Raúl López-Izquierdo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostic tools
  • point-of-care testing
  • prehospital
  • emergency medicine
  • rapid and accurate diagnosis
  • imaging modalities
  • biomarkers
  • AI-driven algorithms

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

9 pages, 378 KiB  
Article
Age-Adjusted Cut-Off Values for Glial Fibrillary Acidic Protein and Ubiquitin Carboxy-Terminal Hydrolase L1 Improve the Diagnostic Accuracy of the Abbott Mild Traumatic Brain Injury Assay
by Ivana Lapić, Dunja Rogić, Matea Bingula, Lea Miklić and Ivan Gornik
Diagnostics 2025, 15(9), 1093; https://doi.org/10.3390/diagnostics15091093 - 25 Apr 2025
Viewed by 125
Abstract
Objectives: To establish age-adjusted cut-off values for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and assess their impact on the diagnostic performance of the mild traumatic brain injury (mTBI) assay. Methods: The study included 175 adult mTBI [...] Read more.
Objectives: To establish age-adjusted cut-off values for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and assess their impact on the diagnostic performance of the mild traumatic brain injury (mTBI) assay. Methods: The study included 175 adult mTBI patients presenting at the emergency department (ED) within 12 h from head trauma in whom head CT scan was performed. GFAP and UCH-L1 were measured using chemiluminescence immunoassays on an Abbott analyzer (Abbott Laboratories, USA). Results: Using manufacturer’s defined cut-offs (GFAP < 35 ng/L, UCH-L1 < 400 ng/L), the mTBI assay exhibited diagnostic sensitivity (Se) of 93.1%, specificity (Sp) of 28.8%, negative predictive value (NPV) of 95.5% and a positive predictive value (PPV) of 20.6%. In the subgroup of patients aged under 50, Se and NPV were below 100% (i.e., 75.0% and 92.3%), due to two false negative mTBI results. Age-adjusted cut-offs were defined for three patient groups, ≤49 years, 50–69 years and ≥70 years, and were set to 22.4, 37.0 and 62.3 ng/L for GFAP, and 349.3, 351.6 and 369.0 ng/L for UCH-L1. Using these cut-offs, in all patient groups Se and NPV were 100%, while increased Sp was obtained in patients older than 50 years. Conclusions: Diagnostic Se and NPV can be improved by the use of age-adjusted cut-offs. In this way, the triage protocol for mTBI and head CT scan can be refined, further contributing to the optimization of the diagnostic management of mTBI patients at the ED. Full article
(This article belongs to the Special Issue Emergency Medicine: Diagnostic Insights)
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