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Editorial Board Members' Collection Series: Diagnostic Approaches to Gastrointestinal and...
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Editorial Board Members' Collection Series: Diagnostic Approaches to Gastrointestinal and Pancreatic Diseases

A topical collection in Diagnostics (ISSN 2075-4418). This collection belongs to the section "Pathology and Molecular Diagnostics".

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Editors

Dr. Paolo Aseni

E-Mail Website
Collection Editor
1. Department of Emergency, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy
2. Morfologia Umana Macroscopica, Dipartimento Di Scienze Biomediche E Cliniche “L. Sacco”, Università Degli Studi Di Milano, Milan, Italy
Interests: pancreatitis; emergencies in organ transplantation; acute liver failure; acute postoperative complications; post-operative hemodynamic monitoring; acute gastrointestinal bleeding; complications in portal hypertension; training and simulation in the emergency department
Dr. Ervin Toth

E-Mail Website
Collection Editor
Department of Gastroenterology, Skåne University Hospital, Lund University, Malmö, Sweden
Interests: diagnostic and therapeutic gastrointestinal endoscopy; colonoscopy; capsule endoscopy; colorectal cancer
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

Gastrointestinal and pancreatic diseases are a significant global health concern, necessitating precise and timely diagnoses for effective patient care. We invite research papers focusing on innovative diagnostic methods to further our understanding of these conditions.

We encourage submissions that explore recent advancements in diagnostic technologies, such as cutting-edge imaging modalities and biomarker discoveries. It is our aim to share insights on how these approaches can enhance diagnostic accuracy and expedite patient treatment, spanning common gastroenterological and pancreatic disorders to rare and complex ailments.

Additionally, we welcome research on genetics and molecular diagnostics in identifying hereditary gastrointestinal and pancreatic conditions. Emphasizing the role of artificial intelligence and machine learning in data analysis for gastroenterology and pancreatic disorders is also encouraged.

Your contributions may significantly impact patient well-being and advance gastroenterology diagnostics. We await your valuable insights.

Dr. Paolo Aseni
Dr. Ervin Toth
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal diseases
  • diagnostics
  • biomarkers
  • imaging techniques
  • precision medicine
  • EUS
  • pancreatic diseases
  • inflammatory bowel diseases

Published Papers (4 papers)

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2025

Jump to: 2024

13 pages, 531 KiB  
Article
Hypertriglyceridemia-Induced and Alcohol-Induced Acute Pancreatitis—A Severity Comparative Study
by Monica Grigore, Daniel Vasile Balaban, Mariana Jinga, Florentina Ioniță-Radu, Raluca Simona Costache, Andrada Loredana Dumitru, Ionela Maniu, Mihaela Badea, Laura Gaman and Săndica Bucurică
Diagnostics 2025, 15(7), 882; https://doi.org/10.3390/diagnostics15070882 - 1 Apr 2025
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Abstract
Background: Alcohol use and hypertriglyceridemia are the second and third common causes of acute pancreatitis after choledocholithiasis. Still, few studies directly compare the severity and outcomes of these two groups, which share pathophysiology pathways. Methods: In our study, we compared the biologic profile, [...] Read more.
Background: Alcohol use and hypertriglyceridemia are the second and third common causes of acute pancreatitis after choledocholithiasis. Still, few studies directly compare the severity and outcomes of these two groups, which share pathophysiology pathways. Methods: In our study, we compared the biologic profile, severity according to the Atlanta classification and Balthazar index, intensive care unit admissions, and mortality between patients with hypertriglyceridemia-induced pancreatitis (HTGP) and alcohol-induced acute pancreatitis (AAP). A total of 78 patients were included in this study, 37.17% of which had HTGP, and 62.82% had AAP. Results: HTGP was more severe in terms of the Atlanta revised classification severity assessment (82.76% vs. 46%, p = 0.014), led to more extended hospitalizations (p = 0.024), and resulted in similar serum CRP levels among patients, with a significant difference regarding median serum fibrinogen values (739 vs. 563 mg/dL, p = 0.030) and necrotizing forms (24.13% vs. 10.20%). Hyponatremia was more significant in HTGP patients compared with AAP patients (130 vs. 137 mmol/L, p < 0.000). No differences were found in other inflammation indexes such as NLR (neutrophil count/lymphocyte count), PLR (platelet count/lymphocyte count), MLR (monocyte/lymphocyte count), SII (systemic immune-inflammation index), or SIRI (systemic inflammation response index). Conclusions: The pattern of acute pancreatitis is related to its etiology and may have different grades of severity. In our study, we found that hypertriglyceridemia-induced pancreatitis required twice as many admissions to the intensive care unit and was associated with lower serum sodium levels, and almost twice as many patients with HTGP had moderate or severe forms of acute pancreatitis compared to alcohol-induced pancreatitis cases. Full article
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2024

Jump to: 2025

13 pages, 594 KiB  
Article
Diagnostic Performance of Clinical and Routine Laboratory Data in Acute Mesenteric Arterial Occlusion—An International Multicenter Study
by Yasmin Soltanzadeh-Naderi, Annika Reintam Blaser, Martin Björck, Alexandre Nuzzo, Joel Starkopf, Alastair Forbes, Marko Murruste, Kadri Tamme, Peep Talving, Anna-Liisa Voomets, Merli Koitmäe, Miklosh Bala, Zsolt Bodnar, Dumitru Casian, Zaza Demetrashvili, Mario D’Oria, Virginia Dúran Muñoz-Cruzado, Hanne Fuglseth, Moran Hellerman Itzhaki, Benjamin Hess, Karri Kase, Kristoffer Lein, Matthias Lindner, Cecilia I. Loudet, Damian J. Mole, Sten Saar, Maximilian Scheiterle, Kenneth Voon, Jonas Tverring and Stefan Acostaadd Show full author list remove Hide full author list
Diagnostics 2024, 14(23), 2705; https://doi.org/10.3390/diagnostics14232705 - 30 Nov 2024
Cited by 1 | Viewed by 1114
Abstract
Background: There are no clinical or laboratory markers that can diagnose acute mesenteric ischemia (AMI) accurately. This study aimed to find differences in clinical and laboratory markers between arterial occlusive AMI and other acute abdominal diseases where AMI was initially suspected. Methods: This [...] Read more.
Background: There are no clinical or laboratory markers that can diagnose acute mesenteric ischemia (AMI) accurately. This study aimed to find differences in clinical and laboratory markers between arterial occlusive AMI and other acute abdominal diseases where AMI was initially suspected. Methods: This was a post hoc study of an international prospective multicenter study where data on patients with suspected AMI were collected. Independent factors associated with arterial occlusive AMI were evaluated in a multivariable logistic regression analysis. Results: The number of patients with arterial occlusive AMI was 231, consisting of thrombotic (n = 104), embolic (n = 61), and indeterminate (n = 66) occlusions. The non-AMI group included 287 patients, of whom 128 had strangulated bowel obstruction. Current smoking (odds ratio [OR] 2.56, 95% confidence interval [CI] 1.31–5.03), hypertension (OR 2.08, 95% CI 1.09–3.97), bowel emptying (OR 3.25, 95% CI 1.59–6.63), and leukocytosis (OR 1.54, 95% CI 1.14–2.08) at admission were independently associated with arterial occlusive AMI compared to the non-AMI group. Conclusions: This study found clinical and laboratory data to be associated with arterial occlusive AMI in patients with suspicion of AMI, which can possibly be of value in screening for arterial occlusive AMI at the emergency department. Further studies are needed to find more accurate diagnostic markers. Full article
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13 pages, 2736 KiB  
Article
Circulating IgG Fragments for Gastric Cancer and Esophageal Cancer
by Eugene I. Goufman, Nataliia B. Tikhonova, Andrey P. Aleksankin, Karina B. Gershkovich, Alexander A. Stepanov, Irina I. Stepanova, Liudmila M. Mikhaleva, Natalia V. Nizyaeva, Olga V. Kovaleva, Alexander A. Alferov, Yury B. Kuzmin and Nikolay E. Kushlinskii
Diagnostics 2024, 14(13), 1396; https://doi.org/10.3390/diagnostics14131396 - 30 Jun 2024
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Abstract
Blood serum of patients with gastric (n = 68) and esophageal (n = 43) cancer was assessed for proteolytic fragments of IgG. Serum samples of 20 healthy donors were used as a control. We analyzed indicators of hemostasis (prothrombin time, fibrinogen, [...] Read more.
Blood serum of patients with gastric (n = 68) and esophageal (n = 43) cancer was assessed for proteolytic fragments of IgG. Serum samples of 20 healthy donors were used as a control. We analyzed indicators of hemostasis (prothrombin time, fibrinogen, plasminogen activity, a2-antiplasmin activity, protein C activity) in blood plasma and the level of total IgG in the blood serum. The median IgG-LysK of healthy donors was lower than in esophageal cancer and in patients with gastric cancer. ROC-analysis showed high sensitivity (91%) and specificity (85%) in the group with esophageal cancer but 68% and 85%, respectively, in patients with gastric cancer. Analysis of false negatives IgG-LysK in cancer patients showed that most patients had an advanced stage of cancer accompanied by metastases. Total IgG in the plasma of patients with false-negative IgG-LysK values was 30% lower than in samples with positive values, while the level of a2-antiplasmin was increased and the prothrombin time was shorter. These changes in blood homeostasis may be the reason for an increase in the proportion of false-negative values of the IgG-LysK coefficient. Circulatory IgG-LysK levels increase in the early stages of such cancers as gastric and esophageal cancers. Thus, when used in a panel with other more specific markers for these pathologies, this indicator can significantly increase the early detection of cancer. Full article
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16 pages, 1694 KiB  
Article
Assessing Patient Radiation Exposure in Endoscopic Retrograde Cholangiopancreatography: A Multicenter Retrospective Analysis of Procedural Complexity and Clinical Factors
by Touko Kaasalainen, Ekaterina Saukko, Outi Lindström, Marianne Udd, Sara Regnér, Arto Saarela, Ervin Toth, Gabriele Wurm Johansson, Anna-Leena Manninen, Juha Grönroos and Leena Kylänpää
Diagnostics 2024, 14(6), 656; https://doi.org/10.3390/diagnostics14060656 - 21 Mar 2024
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Abstract
Background and aims: Endoscopic retrograde cholangiopancreatography (ERCP) procedures can result in significant patient radiation exposure. This retrospective multicenter study aimed to assess the influence of procedural complexity and other clinical factors on radiation exposure in ERCP. Methods: Data on kerma-area product (KAP), air-kerma [...] Read more.
Background and aims: Endoscopic retrograde cholangiopancreatography (ERCP) procedures can result in significant patient radiation exposure. This retrospective multicenter study aimed to assess the influence of procedural complexity and other clinical factors on radiation exposure in ERCP. Methods: Data on kerma-area product (KAP), air-kerma at the reference point (Ka,r), fluoroscopy time, and the number of exposures, and relevant patient, procedure, and operator factors were collected from 2641 ERCP procedures performed at four university hospitals. The influence of procedural complexity, assessed using the American Society for Gastrointestinal Endoscopy (ASGE) and HOUSE complexity grading scales, on radiation exposure quantities was analyzed within each center. The procedures were categorized into two groups based on ERCP indications: primary sclerosing cholangitis (PSC) and other ERCPs. Results: Both the ASGE and HOUSE complexity grading scales had a significant impact on radiation exposure quantities. Remarkably, there was up to a 50-fold difference in dose quantities observed across the participating centers. For non-PSC ERCP procedures, the median KAP ranged from 0.9 to 64.4 Gy·cm2 among the centers. The individual endoscopist also had a substantial influence on radiation dose. Conclusions: Procedural complexity grading in ERCP significantly affects radiation exposure. Higher procedural complexity is typically associated with increased patient radiation dose. The ASGE complexity grading scale demonstrated greater sensitivity to changes in radiation exposure compared to the HOUSE grading scale. Additionally, significant variations in dose indices, fluoroscopy times, and number of exposures were observed across the participating centers. Full article
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