Emerging Biomarkers for Immune Checkpoint Inhibitors in Tumors
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 3578
Special Issue Editors
Interests: cancer immunity and immunotherapy resistance mechanism; autophagy, energy metabolism and carcinogenesis
Interests: tumor diagnostics and therapeutics; cancer immunity
Special Issue Information
Dear Colleagues,
Immune checkpoint inhibitors (ICIs) have recently taken off as promising immuno-therapeutic methods that have slowed down the progress of various cancers and equipped patients with survival advantages. However, the long-term respondents tally is less than 20% of the population. This low response rate warrants the need for biomarkers which can dynamically provide insight into the possible response of patients to ICIs. Biomarkers are biological molecules that predict the pathological state of patients and the potential response they will elicit to ICIs. Predictive biomarkers play a crucial role in analyzing the effects of ICI therapy on patients and potentially filtering out patients who will certainly benefit from ICIs. In this way, resources in immunotherapy can be rationalized better and the healthcare system can administer an alternative mode of treatment to the non-responsive group of patients. Herein, precision therapy can be performed according to the possible responsiveness and needs of patients. Potential biomarkers for cancer immunotherapy, such as PD-1/PD-L1, total mutation burden (TMB), and tumor-infiltrating lymphocytes (TILs), etc., may be used to assist future application of immunotherapy and patient selection in clinical practice.
The aim of this Special Issue is to look into the emerging biomarkers for immune checkpoint inhibitors in tumors. We welcome both original research articles and reviews.
Dr. Honglei Chen
Dr. Hitoshi Dejima
Dr. Min Peng
Guest Editors
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Keywords
- biomarkers
- immune checkpoint
- immune checkpoint inhibitors
- immunotherapy
- total mutation burden
- PD-1/PD-L1
- precision therapy
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