Special Issue "Diagnosis and Management of Bone Infection"

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Mr. Nima Heidari
E-Mail Website
Guest Editor
Consultant Orthopaedic and Trauma Surgeon, Orthopaedic Surgeon, Lead for Limb Reconstruction, The Royal London Limb Reconstruction Service, Royal London Hospital, Barts Health NHS Trust, UK
Interests: Bone Infection; Limb deformity; Limb Reconstruction; Complex trauma; joint preservation
Prof. Dr. Andrej Trampuz
E-Mail Website
Guest Editor
Consultant for Infectious Diseases, Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany
Interests: Implant associated infection; Biofilm

Special Issue Information

Dear Colleagues,

Bone infection represents a diagnostic and therapeutic challenge. Accurate diagnosis and correct surgical treatment in combination with targeted antimicrobials are prerequisites to achieving the best outcome. The aim of treatment is the eradication of the infection and the restoration of skeletal anatomy in order to maintain and regain bone biological function. The management of bone infection needs surgical intervention to remove dead and infected tissue and reestablish skeletal (bone and soft tissue) integrity. One of the challenges is the targeting of microorganisms growing within bone and soft tissues and on medical devices in the form of biofilm, which are difficult to detect and eradicate. In this Special Issue, concepts related to the prevention and treatment of infection associated with open fractures and internal fracture fixation will be reviewed. The key to success is a multi-disciplinary team approach integrating clinical expertise, diagnostic algorithms, appropriate surgery, and local and systemic antimicrobials. It is also necessary to consider some specific aspects in special circumstances such as the presence of diabetic foot infections, peri-prosthetic joint infections, and infection in children that require a nuanced approach. Studies in these areas are also welcomed.

Dr. Nima Heidari
Dr. Andrej Trampuz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Basics of biofilm
  • Action of biofilm-active antibiotics
  • Fracture-related infections – Pathogenesis, classification, Diagnostic criteria
  • Diagnostic approach – preoperative & intraoperative tests
  • Surgical principles – Algorithmic approach
  • Management of bone defects
  • Management of soft tissue defects
  • Antimicrobial principles – local and systemic antibiotics
  • Novel and innovative approaches: bacteriophages, implant coatings, enzymes, electricity, sonication

Published Papers

This special issue is now open for submission.
Back to TopTop