Diagnosis and Management of Primary Liver Cancers

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 781

Special Issue Editors


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Guest Editor
1. Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
2. Villa Serena Foundation for Research, 65013 Città Sant’Angelo, Pescara, Italy
Interests: general surgery; endocrine surgery; thyroid diseases; surgical education
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Guest Editor
Unit of General Surgery, Ospedale Floraspe Renzetti, 66034 Lanciano, CH, Italy
Interests: general surgery; emergency surgery; translational research; surgical education
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Special Issue Information

Dear Colleagues,

Primary liver cancers are increasing in incidence and mortality. Unfortunately, the diagnosis of these cancers is often made late due to their silent nature and invasiveness. At present, the understanding of primary liver carcinogenesis is essential to develop more efficient combinations of immune inhibitors and chemotherapies together with surgical and non-surgical strategies.

Improved therapeutic protocols for patients with advanced or metastatic primary liver cancer are currently advocated. For this Special Issue, submissions of clinical and experimental research that focus on the diagnosis and treatment of primary liver cancers with personal experience are invited. Studies designed to clarify the following topics are welcome for submissions: diagnosis and management of cholangiocarcinoma and diagnosis of biliary intraepithelial neoplasm and intraductal papillary neoplasm. In addition, studies on ecoendoscopy and artificial intelligence in the research field of primary liver cancer are strongly encouraged.

Dr. Roberto Cotellese
Dr. Federico Selvaggi
Guest Editors

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Keywords

  • hepatocellular carcinoma
  • cholangiocarcinoma
  • radiofrequency ablation
  • ecoendoscopy
  • chemotherapy
  • immunotherapy
  • surgery

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Published Papers (1 paper)

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Review

25 pages, 1797 KiB  
Review
Diagnosis of Cholangiocarcinoma: The New Biological and Technological Horizons
by Federico Selvaggi, Loris Riccardo Lopetuso, Andrea delli Pizzi, Eugenia Melchiorre, Marco Murgiano, Alessio Lino Taraschi, Roberto Cotellese, Michele Diana, Marco Vivarelli, Federico Mocchegiani, Teresa Catalano and Gitana Maria Aceto
Diagnostics 2025, 15(8), 1011; https://doi.org/10.3390/diagnostics15081011 - 16 Apr 2025
Viewed by 398
Abstract
The diagnosis of cholangiocarcinoma (CCA) remains challenging. Although new technologies have been developed and validated, their routine use in clinical practice is needed. Conventional cytology obtained during endoscopic retrograde cholangiopancreatography-guided brushings is the first-line technique for the diagnosis of CCA, but it has [...] Read more.
The diagnosis of cholangiocarcinoma (CCA) remains challenging. Although new technologies have been developed and validated, their routine use in clinical practice is needed. Conventional cytology obtained during endoscopic retrograde cholangiopancreatography-guided brushings is the first-line technique for the diagnosis of CCA, but it has shown limited sensitivity when combined with endoscopic ultrasound-guided biopsy. Other diagnostic tools have been proposed for the diagnosis of CCA, with their respective advantages and limitations. Cholangioscopy with biopsy or cytology combined with FISH analysis, intraductal biliary ultrasound and confocal laser microscopy have made significant advances in the last decade. More recently, developments in the analytical “omics” sciences have allowed the mapping of the microbiota of patients with CCA, and liquid biopsy with proteomic and extracellular vesicle analysis has allowed the identification of new biomarkers that can be incorporated into the predictive diagnostics. Furthermore, in the preoperative setting, radiomics, radiogenomics and the integrated use of artificial intelligence may provide new useful foundations for integrated diagnosis and personalized therapy for hepatobiliary diseases. This review aims to evaluate the current diagnostic approaches and innovative translational research that can be integrated for the diagnosis of CCA. Full article
(This article belongs to the Special Issue Diagnosis and Management of Primary Liver Cancers)
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