Diagnostic, Predictive and Prognostic Biomarkers for Neurodegenerative Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 403

Special Issue Editor


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Guest Editor
Department of Anatomy, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
Interests: neurodegenerative disorders; Epilepsy; Parkinson’s disease; Alzheimer’s disease
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Special Issue Information

Dear Colleagues,

Neurodegenerative diseases are increasingly prevalent pathologies that are unfortunately occurring at younger and younger ages. Although many of these pathologies do not yet have a well-defined substrate, their evolution can be assessed through serological biomarkers and imaging procedures. Moreover, the effectiveness of treatment can be assessed through paraclinical analyses. There is still a need to develop more targeted therapeutic strategies for neurodegenerative diseases, including early detection in the presymptomatic phase with the help of serological biomarkers that are easy to quantify and reproduce. Moreover, imaging studies corroborated by serological investigations in dynamics can be correlated with the evolution of the disease, allowing the assessment of the effectiveness of treatment. Therefore, we invite you to share your experience regarding these pathologies in order to establish new therapeutic approaches and facilitate the early discovery of neurodegenerative diseases.

Dr. Ionica Pirici
Guest Editor

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Keywords

  • neurodegenerative diseases
  • biomarkers
  • medical imaging
  • pathology

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Published Papers (1 paper)

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10 pages, 962 KB  
Brief Report
Anti-NMDA-Receptor GluN1 Antibody Serostatus Is Robust in Acute Severe Stroke
by Pia Sophie Sperber, Benjamin Hotter, Matthias Endres, Harald Prüss and Andreas Meisel
Diagnostics 2025, 15(24), 3132; https://doi.org/10.3390/diagnostics15243132 - 9 Dec 2025
Viewed by 185
Abstract
Background: Anti-N-methyl-D-aspartate IgM and IgA antibodies (NMDAR1-abs) are associated with unfavorable stroke outcomes and may be risk factors thereof. However, to utilize NMDAR1-abs serostatus for risk assessment in acute stroke, it is crucial to understand the robustness of serostatus during this phase. Therefore, [...] Read more.
Background: Anti-N-methyl-D-aspartate IgM and IgA antibodies (NMDAR1-abs) are associated with unfavorable stroke outcomes and may be risk factors thereof. However, to utilize NMDAR1-abs serostatus for risk assessment in acute stroke, it is crucial to understand the robustness of serostatus during this phase. Therefore, we investigated the robustness of NMDAR1-abs serostatus and titer levels up to seven days after stroke. Methods: In this exploratory analysis of the multicenter STRAWINSKI trial (identifier: NCT01264549), patients with severe ischemic stroke (NIHSS ≥ 9) in the middle cerebral artery territory were included. The first blood sample was taken within 36 h and then daily from day two to seven after stroke. NMDAR1-abs immunoglobulin (Ig)A and IgM were assessed in serum using cell-based assays. We initially measured NMDAR1-abs in the total cohort on day 1. Subsequently, in samples from seropositive and matched seronegative patients, we measured NMDAR1-abs on each following day. Titer dilutions started from 1:10 up to 1:1000. Seropositivity was defined as any titer > 0. Results: Out of 171 patients (mean age = 76 [SD = 11], median NIHSS = 15 [IQR = 12–18]), 16 (9%) individuals were seropositive. Seropositive patients remained seropositive and matched seronegative participants remained seronegative over sequential measurements. Although titer levels remained largely unchanged, some patients showed fluctuating titers. Conclusions: The status of NMDAR1-abs seropositivity is stable during acute stroke, with little to no variation in titer levels. Full article
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