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Diagnostics
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Recent Advances in Gynecologic Oncology: Diagnosis and Management, 2nd Edition
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Recent Advances in Gynecologic Oncology: Diagnosis and Management, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2297

Special Issue Editor

Prof. Dr. Jure Knez

E-Mail Website
Guest Editor
Department of Gynaecology and Obstetrics, Faculty of Medicine University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
Interests: endometrial cancer; endometriosis; biomarkers in gynecology; ultrasound; gynecological oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gynecologic oncology is a rapidly evolving field of medicine that integrates knowledge from various fields and often requires a multidisciplinary approach when planning treatment. Clinical, radiological, and molecular information must all be included in the diagnosis and treatment plan. Recent molecular advances in endometrial and ovarian cancer have improved our understanding of these diseases and their response to treatment and moved the trend of treatment toward personalized medicine. There are, however, still many questions that remain unanswered, such as the best approach in advanced ovarian cancer, the role of neoadjuvant chemotherapy in fertility-sparing treatment of cervical cancer, and many more. This Special Issue aims to answer these seemingly unanswerable questions.

Prof. Dr. Jure Knez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrial cancer
  • ovarian cancer
  • cervical cancer
  • vulvar cancer
  • ultrasound
  • colposcopy
  • diagnosis and management

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Published Papers (3 papers)

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Research

9 pages, 622 KiB  
Article
Experiences of Self-Collected Human Papilloma Virus (HPV) Testing Among Women Aged 20 to 65 Years in Ho Chi Minh City, Vietnam
by Ai H. T. Pham, Thao H. Ha, Thanh Q. Le, Dat Q. Nguyen and Tuan M. Vo
Diagnostics 2025, 15(8), 968; https://doi.org/10.3390/diagnostics15080968 - 10 Apr 2025
Viewed by 306
Abstract
Background/Objectives: To assess the correct sampling rates and self-collection satisfaction levels among female residents aged 25 to 64 years during first-time HPV testing in the communities of Ho Chi Minh City. Methods: An observational study was conducted on self-collection for HPV testing in [...] Read more.
Background/Objectives: To assess the correct sampling rates and self-collection satisfaction levels among female residents aged 25 to 64 years during first-time HPV testing in the communities of Ho Chi Minh City. Methods: An observational study was conducted on self-collection for HPV testing in communities from January to December 2024. The study employed a probability proportional to size sampling method, involving self-collected sampling and post-collection direct interviews. Results: The data show that 99.9% [95% CI = 0.99–1] of 775 women successfully collected their own samples during a first-time HPV testing process. The self-collection satisfaction rate was 80.4% [95% CI = 0.77–0.83]. Conclusions: Self-collected sampling for HPV testing has a very high success rate in communities. Moreover, women who feel confident in self-collection tend to have higher satisfaction rates with this new method. Therefore, self-collection sampling should be widely adopted for early cervical cancer screenings to test for high-risk HPV. It is essential to provide careful instructions and mobilization to encourage women’s confidence in performing self-collections. Full article
(This article belongs to the Special Issue Recent Advances in Gynecologic Oncology: Diagnosis and Management, 2nd Edition)
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11 pages, 5215 KiB  
Article
SonoElastoColposcopy: A New Tool for Cervical Dysplasia Assessment
by José Antonio Sainz-Bueno, Cristina Fernández-Conde de Paz, Ainhoa Holgado, José María Romo, Teresa Reyes-Sánchez, Fernando Fernández-Palacín and José Antonio García-Mejido
Diagnostics 2025, 15(7), 806; https://doi.org/10.3390/diagnostics15070806 - 22 Mar 2025
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Abstract
Background/Objectives: Up to 30% of cervical dysplastic lesions are missed by colposcopy alone. We performed a comparative evaluation of the diagnostic capacity for identifying cervical dysplastic lesions between shear wave elastography (SWE) of the endocervix and exocervix, defined as SonoElastoColposcopy (SEC), and colposcopy. [...] Read more.
Background/Objectives: Up to 30% of cervical dysplastic lesions are missed by colposcopy alone. We performed a comparative evaluation of the diagnostic capacity for identifying cervical dysplastic lesions between shear wave elastography (SWE) of the endocervix and exocervix, defined as SonoElastoColposcopy (SEC), and colposcopy. Methods: A prospective observational study was conducted in 84 patients indicated for cervical conization surgery (presence of cervical intraepithelial neoplasia 2 or 3 (CIN-2 or 3), adenocarcinoma in situ (AIS), or high-grade suspicious lesions). All patients underwent colposcopy with lesion identification and biopsy, and SEC and SWE evaluation of the endocervix and exocervix with measurement of lesion stiffness (KPa). Cervical lesions identified by colposcopy or SEC were localized in quadrants, and a comparative evaluation of the diagnostic capacity of both techniques was performed in relation to the anatomical pathology of the cone biopsy. Results: A total of 82 women were evaluated (two cases were lost). The mean age was 38.84 ± 8.44 years. Colposcopy was adequate in 95.12% of cases. In SEC, we observed an elasticity in the lesion area of 105.42 ± 36.32 KPa compared to 19.98 ± 9.29 KPa (p < 0.0001) in the healthy area of the exocervix. In the endocervix, the results were 109.8 ± 40.86 KPa versus 18.5 ± 9.07 KPa (p < 0.0001), respectively. The concordance for colposcopy was 0.456 compared to 0.815 (p < 0.05) for SEC. Conclusions: SEC demonstrates a better ability to identify the area of cervical dysplastic lesions than colposcopy. Full article
(This article belongs to the Special Issue Recent Advances in Gynecologic Oncology: Diagnosis and Management, 2nd Edition)
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14 pages, 1230 KiB  
Article
Extracellular Vesicle Characteristics in Local Fluid and Plasma Measured by Nanoparticle Tracking Analysis Can Help Differentiate High-Grade Serous Carcinoma from Benign Ovarian Pathology
by Maruša Herzog, Ivan Verdenik, Katarina Černe and Borut Kobal
Diagnostics 2024, 14(19), 2235; https://doi.org/10.3390/diagnostics14192235 - 7 Oct 2024
Cited by 1 | Viewed by 1296
Abstract
Background: High-grade serous carcinoma (HGSC) is the most lethal of gynecological cancers in developed countries. It usually presents late with non-specific symptoms and most cases are diagnosed at an advanced stage, with 5-year overall survival being around 40%. Biomarkers for screening and early [...] Read more.
Background: High-grade serous carcinoma (HGSC) is the most lethal of gynecological cancers in developed countries. It usually presents late with non-specific symptoms and most cases are diagnosed at an advanced stage, with 5-year overall survival being around 40%. Biomarkers for screening and early diagnosis of this aggressive disease are, thus, a research priority. Extracellular vesicles (EVs) that reflect the cell of origin and that can be isolated from local fluid and plasma by minimally invasive liquid biopsy are such promising biomarkers. Besides EV concentration and molecular profile, which have been the main focus of research for many years, recent studies have also called attention to EV size distribution. The aim of our study was to evaluate the potential of EV concentration and size distribution in local fluid and plasma as diagnostic biomarkers for HGSC. Methods: Paired pretreatment ascites and plasma samples from 37 patients with advanced HGSC and paired pretreatment free peritoneal fluid (FPF) and plasma samples from 40 controls with benign ovarian pathology (BOP) were analyzed using nanoparticle tracking analysis (NTA). Results: We observed a significant difference in EV concentration in local fluid, but not in plasma, between HGSC patients and the control group. We also found a significant difference in EV size distribution in both local fluid and plasma between HGSC patients and the control group. The receiver operating characteristics (ROC) curve analysis of EV characteristics showed excellent diagnostic performance for the mode, D10, and D50 in local fluid and acceptable diagnostic performance for EV concentration and mean EV size in local fluid, as well as for the mode and D10 value in plasma. Conclusions: The results of our study show that EV concentration in local fluid and more importantly EV size distribution in both local fluid and plasma are significantly changed in the presence of HGSC. Future research of size-dependent molecular profiling of EVs could help identify novel diagnostic biomarkers for HGSC. Full article
(This article belongs to the Special Issue Recent Advances in Gynecologic Oncology: Diagnosis and Management, 2nd Edition)
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