Myocarditis: Diagnosis, Prognosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1958

Special Issue Editors


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Guest Editor
First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
Interests: inflammatory cardiomyopathy; dilated cardiomyopathy; myocarditis; hypertrophic cardiomyopathy; arrhythmogenic cardiomyopathy; heart failure; personalized medicine; endomyocardial biopsy; viral myocardial infection

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Guest Editor
First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
Interests: cardiac magnetic resonance; echocardiography; cardiomyopathies; inflammatory cardiomyopathy; heart failure; myocarditis; biomarkers
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Cardiology, University Clinical Center of Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Interests: heart failure; pericardial diseases; myocarditis; pulmonary hypertension

Special Issue Information

Dear Colleagues,

Myocarditis is an inflammatory heart disease induced by infectious or non-infectious causes, frequently triggering immune-mediated pathologic mechanisms, leading to myocardial structural and functional compromise. Due to the large variability of clinical presentation, the unpredictable course of the disease, and the lack of established causative treatments, myocarditis is a major diagnostic and therapeutic challenge in cardiology. Furthermore, an increasing incidence of myocarditis has been observed in recent decades. 

Recent years have seen important progress in available non-invasive diagnostic methods, including biomarkers, serum anti-heart autoantibodies, microRNAs, speckle tracking echocardiography, cardiac magnetic resonance T1 and T2 tissue mapping, and positron emission tomography, which may help to distinguish the underlying pathogenesis and refine the diagnostic workup of myocarditis. However, endomyocardial biopsy is still the diagnostic gold standard.

Nevertheless, there is a significant knowledge gap regarding the pathogenesis of myocarditis, as well as individualized diagnostic and treatment concepts. In particular, new biomarkers, and disease-specific diagnostic and therapeutic strategies are required to adequately manage patients with suspected myocarditis. It is also increasingly recognized that personalized management should also include the implementation of disease-specific therapies.

For this Special Issue, we encourage the submission of manuscripts on any aspects of the pathophysiologic mechanisms, diagnosis (such as novel biomarkers, advances in cardiac imaging modalities, and endomyocardial biopsy), and treatment of myocarditis, including experimental, translational, and clinical research. We accept reviews, short communications, methodology papers, and full-size research papers with a focus on the following aspects:

  • Novel effective diagnostic and/or therapeutic strategies for myocarditis;
  • Approaches to better classify the phenotypes and/or etiologies of myocarditis;
  • New genes, pathomechanisms, and potential drug targets for a particular phenotypes and/or etiologies of myocarditis.

Dr. Krzysztof Ozierański
Dr. Agata Tymińska
Prof. Dr. Arsen D. Ristić
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • myocarditis
  • inflammatory cardiomyopathy
  • dilated cardiomyopathy
  • heart failure
  • immunosuppressive treatment
  • myocardial inflammation
  • personalized medicine
  • endomyocardial biopsy
  • viral myocardial infection
  • biomarkers

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Published Papers (1 paper)

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Research

9 pages, 907 KiB  
Article
Diagnosis of Acute Myocarditis Using Texture-Based Cardiac Magnetic Resonance, with CINE Imaging as a Novel Tissue Characterization Technique
by Evin I. Papalini, Christian L. Polte, Emanuele Bobbio and Kerstin M. Lagerstrand
Diagnostics 2022, 12(12), 3187; https://doi.org/10.3390/diagnostics12123187 - 16 Dec 2022
Cited by 3 | Viewed by 1173
Abstract
Cardiac magnetic resonance (CMR) has emerged as a useful tool in the diagnostic work-up of patients with clinically suspected acute myocarditis (AM), yet the diagnosis remains challenging. The purpose of this proof-of-concept study was to evaluate if data-driven texture analysis has the feasibility [...] Read more.
Cardiac magnetic resonance (CMR) has emerged as a useful tool in the diagnostic work-up of patients with clinically suspected acute myocarditis (AM), yet the diagnosis remains challenging. The purpose of this proof-of-concept study was to evaluate if data-driven texture analysis has the feasibility to automatically distinguish between patients with and without CMR-verified AM using T2-weighted, late gadolinium enhancement, and CINE imaging. In particular, the present study investigated if functional CINE imaging could be used as a novel tissue characterization technique. Twenty patients with clinically suspected AM, separated into CMR-verified (n = 10) and non CMR-verified (n = 10) AM according to the Lake Louise criteria, were retrospectively included. Texture features were extracted from the images, compared on a group level, and correlated to the diagnostic outcome (CMR-verified versus non CMR-verified AM). Several features showed good to excellent reproducibility with very large differences between the groups, and moderate to strong correlation with the diagnostic outcome, suggesting that CMR texture analysis is a promising diagnostic tool for patients with clinically suspected AM. Furthermore, findings indicate that CINE imaging, which is currently used for the evaluation of cardiac function, might be a useful non-contrast-based technique for tissue characterization in patients with clinically suspected AM. Full article
(This article belongs to the Special Issue Myocarditis: Diagnosis, Prognosis and Management)
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