Special Issue "Endodontic Microbiology"

A special issue of Dentistry Journal (ISSN 2304-6767).

Deadline for manuscript submissions: 31 October 2018

Special Issue Editor

Guest Editor
Dr. Prasanna Neelakantan

Discipline of Endodontology, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong, China
Website | E-Mail
Interests: biofilm; quorum sensing; resistance; root canal disinfection

Special Issue Information

Dear Colleagues,

Arguably, one field of dentistry that is being barged with technological advancements is endodontics. However, the etiology of “endodontic disease” is microbial, and treatments should be biologically driven. We have come to understand that pulpal and periradicular infections are biofilm mediated, and that this biofilm affords extraordinary resistance to microbial flora. This is due to biofilm structure, as well as the dynamics of the interactions between the microbial components of a biofilm. While there has been significant advancement in our understanding of microbial biofilms and their role in pulpal and periradicular diseases, much is still a mystery. The launch of this Special Issue, dedicated to “Endodontic Microbiology”, is thus timely, and aims to bring our readers exemplary work on this subject matter, both from a basic science perspective and from a translational perspective. We invite researchers to submit papers on this subject, which will enhance our understanding of endodontic microbiology.

Dr. Prasanna Neelakantan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • EPS matrix
  • intracanal medicaments
  • endotoxin/lipopolysaccharide
  • Lipoteichoic acid
  • nanoparticles
  • persistent infection
  • quorum sensing
  • root canal disinfection
  • root canal irrigants
  • reinfection
  • virulence

Published Papers (5 papers)

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Editorial

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Open AccessEditorial Endodontic Microbiology—A Special Issue of Dentistry Journal
Dent. J. 2018, 6(2), 14; https://doi.org/10.3390/dj6020014
Received: 25 December 2017 / Revised: 1 May 2018 / Accepted: 1 May 2018 / Published: 17 May 2018
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Abstract
Understanding microbiology, specifically biofilm biology is an essential component of creating targeted therapeutic modalities that are effective and efficient.[...] Full article
(This article belongs to the Special Issue Endodontic Microbiology)

Research

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Open AccessFeature PaperArticle Green Tea Polyphenol Epigallocatechin-3-Gallate-Stearate Inhibits the Growth of Streptococcus mutans: A Promising New Approach in Caries Prevention
Dent. J. 2018, 6(3), 38; https://doi.org/10.3390/dj6030038
Received: 7 July 2018 / Revised: 30 July 2018 / Accepted: 1 August 2018 / Published: 6 August 2018
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Abstract
Streptococcus mutans (S. mutans) is the main etiological bacteria present in the oral cavity that leads to dental caries. All of the S. mutans in the oral cavity form biofilms that adhere to the surfaces of teeth. Dental caries are infections
[...] Read more.
Streptococcus mutans (S. mutans) is the main etiological bacteria present in the oral cavity that leads to dental caries. All of the S. mutans in the oral cavity form biofilms that adhere to the surfaces of teeth. Dental caries are infections facilitated by the development of biofilm. An esterified derivative of epigallocatechin-3-gallate (EGCG), epigallocatechin-3-gallate-stearate (EGCG-S), was used in this study to assess its ability to inhibit the growth and biofilm formation of S. mutans. The effect of EGCG-S on bacterial growth was evaluated with colony forming units (CFU) and log reduction; biofilm formation was qualitatively determined by Congo red assay, and quantitatively determined by crystal violet assay, fluorescence-based LIVE/DEAD assays to study the cell viability, and scanning electron microscopy (SEM) was used to evaluate the morphological changes. The results indicated that EGCG-S was able to completely inhibit growth and biofilm formation at concentrations of 250 µg/mL. Its effectiveness was also compared with a commonly prescribed mouthwash in the United States, chlorhexidine gluconate. EGCG-S was shown to be equally effective in reducing S. mutans growth as chlorhexidine gluconate. In conclusion, EGCG-S is potentially an anticariogenic agent by reducing bacterial presence in the oral cavity. Full article
(This article belongs to the Special Issue Endodontic Microbiology)
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Review

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Open AccessReview Historical and Contemporary Perspectives on the Microbiological Aspects of Endodontics
Dent. J. 2018, 6(4), 49; https://doi.org/10.3390/dj6040049
Received: 30 August 2018 / Revised: 20 September 2018 / Accepted: 20 September 2018 / Published: 22 September 2018
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Abstract
The microbiota of the oral cavity plays a significant role in pulpal and periapical diseases. Historically, 100 years ago little was known on microbiota, but after a century of investigations, only now can many of the intimate secrets of microbial growth, expansion, persistence,
[...] Read more.
The microbiota of the oral cavity plays a significant role in pulpal and periapical diseases. Historically, 100 years ago little was known on microbiota, but after a century of investigations, only now can many of the intimate secrets of microbial growth, expansion, persistence, communal activities, and virulence be revealed. However, with the capabilities of the microbiota for mutation, quorum sensing, and information transference, researchers are hard-pressed to keep up with both the changes and challenges that an amazingly wide range of bacterial species pose for both the scientist and clinician. Fortunately, the development and expansion of a vast array of molecular biological investigative techniques have enabled dentistry and its associated medical fields to attempt to keep pace with the wide and fascinating world of oral microbiology. Full article
(This article belongs to the Special Issue Endodontic Microbiology)
Open AccessReview Light Activated Disinfection in Root Canal Treatment—A Focused Review
Dent. J. 2018, 6(3), 31; https://doi.org/10.3390/dj6030031
Received: 13 June 2018 / Revised: 28 June 2018 / Accepted: 5 July 2018 / Published: 10 July 2018
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Abstract
Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the
[...] Read more.
Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the effectiveness of this mode of root canal disinfection. While most studies offer an important understanding of the effectiveness of LAD on monospecies biofilms, few have offered credence to the fact that infections of the root canal system are mediated by polymicrobial biofilms. Hence, it is imperative to understand the effect of LAD on polymicrobial biofilms both in terms of microbial killing and the changes in the biofilm architecture. The aim of this review was to systematically review the literature to evaluate the effect of LAD on dual and multispecies biofilms and demonstrate the antibiofilm effect of LAD. Two databases (PubMed and Scopus) were searched to identify eligible studies using a combination of key words. These studies were reviewed to draw conclusions on the effect of LAD on dual and multi species biofilm and the antibiofilm effect of LAD. It was found that LAD alone may be unable to eradicate dual and multispecies biofilms, but it may enhance the effect of conventional canal debridement strategies. Novel formulations of photosensitizers with nanoparticles showed the potential to inhibit biofilm formation and/or disrupt the biofilm architecture. Full article
(This article belongs to the Special Issue Endodontic Microbiology)
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Other

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Open AccessCase Report Successful Regenerative Endodontic Procedure of a Nonvital Immature Permanent Central Incisor Using Amniotic Membrane as a Novel Scaffold
Dent. J. 2018, 6(3), 36; https://doi.org/10.3390/dj6030036
Received: 20 June 2018 / Revised: 14 July 2018 / Accepted: 17 July 2018 / Published: 2 August 2018
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Abstract
Successful regenerative endodontic procedure was performed in nonvital immature permanent central incisor (Stage-4 root development) using human amniotic membrane (HAM) as a novel scaffold. The treatment was performed according to the American Association of Endodontics guidelines with minimal canal instrumentation, 1% Sodium hypochlorite
[...] Read more.
Successful regenerative endodontic procedure was performed in nonvital immature permanent central incisor (Stage-4 root development) using human amniotic membrane (HAM) as a novel scaffold. The treatment was performed according to the American Association of Endodontics guidelines with minimal canal instrumentation, 1% Sodium hypochlorite as irrigant and calcium hydroxide as intracanal medicament. During the second appointment, HAM was placed as a scaffold and Biodentine™ was layered over the HAM with glass ionomer cement and resin composite as coronal seal. Preoperative and post-operative cone beam computed tomography (at three years) was taken to assess the treatment outcome. The resolution of disease process and increase in canal width, as well as positive response to pulp sensitivity tests, were observed by the end of three years. There was approximately 78–86% reduction in the volume of periapical lesion size. This case report confirms that HAM can be used as a scaffold material for successful regenerative endodontic procedure (REP). Full article
(This article belongs to the Special Issue Endodontic Microbiology)
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