Microbial Biofilms and Host Immune Response
A special issue of Microbiology Research (ISSN 2036-7481).
Deadline for manuscript submissions: closed (30 July 2023) | Viewed by 5184
Special Issue Editor
Interests: antimicrobial therapeutics; biofilms; multifunctional materials; infection-immunity interrelationships
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The human body is home to a large number of microorganisms belonging to various kingdoms. Under normal circumstances, the host surmounts an immune response that keeps pathogens at bay. However, when dysbiosis strikes under conditions unfavorable to the host, the pathogens overwhelm the otherwise remarkably effective host immune system to cause disease. As such, biofilm entities are tolerant to most antimicrobials, and antimicrobial resistance is a growing concern. Novel anti-virulent strategies are now emerging where microbes do not have a sufficient incentive to develop resistance mechanisms. On the other side of the spectrum, rapid killing approaches such as antimicrobial peptides are also being developed. An innovative approach is reprogramming host immune cells to surmount a profound attack to kill pathogens. Indeed, pathogens are no less smart either. They rapidly devise escape mechanisms such as internalization into host cells to thwart efforts by the host immune mechanisms. To deliver efficient therapeutics that will stand the test of time, understanding and acknowledging the intricate balance between infection and immunity are critical. In line with this philosophy, this Special Issue invites reviews and original research submissions from scientists in the areas of microbial (bacterial and fungal) biofilms, impact of biofilms on host immune and non-immune cells, model systems to study microbe–host interactions, novel antimicrobial therapeutics, immunomodulatory approaches and multi-functional therapeutics.
Dr. Prasanna Neelakantan
Guest Editor
Manuscript Submission Information
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Keywords
- biofilm
- infection
- macrophage
- keratinocyte
- host immune response
- antimicrobial
- immunomodulation
- anti-virulence
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