High-Grade Neuroendocrine Neoplasms
A special issue of Current Oncology (ISSN 1718-7729).
Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 2944
Special Issue Editor
Special Issue Information
Dear Colleagues,
High-grade neuroendocrine neoplasms (NENs) are an increasingly encountered entity among providers who care for patients with NENs in general. High-grade NENs can either be well-differentiated grade 3 neuroendocrine tumors (G3 NETs) or poorly differentiated neuroendocrine carcinomas (NECs). Until relatively recently, G3 NETs were not recognized as a separate entity.
The current classification of high-grade (grade 3, G3) NENs clearly separates G3 NETs from NECs, but the distinction can be challenging for pathologists. Their natural history, response to therapy, and prognosis are very different, and only a few prospective trials have specifically addressed each entity within the G3 NEN spectrum.
This Special Issue aims to provide up-to-date information on the increasingly complex management of patients with G3 NENs. The role of the pathologist and the increasing role of molecular analysis will be discussed, and these discussions will be followed by reviews concerning the management of G3 NENs. As the management of G3 NETs differs substantially from the management of NECs, it will be discussed in a separate section. The current status of systemic therapy for NECs and the expanding roles of molecular testing and targeted therapy will be covered in detail.
We encourage all contributors, ideally a diverse group of contributors from different regions of the world, to add their voice and perspectives to the current state of the biology and management of patients with high-grade NENs.
Dr. Thorvardur Halfdanarson
Guest Editor
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Keywords
- neuroendocrine tumor
- neuroendocrine carcinoma
- small cell carcinoma
- large cell carcinoma
- chemotherapy
- immunotherapy
- peptide receptor radionuclide therapy
- alpha particle therapy
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