Advances in Melanoma: From Pathogenesis to Personalized Therapy

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Dermato-Oncology".

Deadline for manuscript submissions: 14 November 2025 | Viewed by 177

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Guest Editor
Department of Oncology, University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada
Interests: skin cancer; prostate cancer; lung cancer; CNS cancer; epidemiology; outcome research; merkel cell carcinoma; database
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Special Issue Information

Dear Colleagues,

This Special Issue will focus on the latest clinical advancements in melanoma management, emphasizing personalized treatment strategies and real-world applications. Contributions will highlight the evolving role of targeted therapies (BRAF/MEK inhibitors) and immunotherapy (PD-1/CTLA-4 blockade) in improving survival outcomes in advanced melanoma. Key discussions in this area include predictive biomarkers for treatment selection, strategies to overcome therapy resistance, and the integration of novel combination therapies into clinical practice. This Special Issue will also explore emerging diagnostic tools, such as liquid biopsies and imaging advancements, for early detection and monitoring. Additionally, real-world data on treatment sequencing, adjuvant therapy optimization, and long-term survivorship will be addressed. By bridging translational research and clinical practice, this Special Issue will provide actionable insights for oncologists to utilize in enhancing melanoma care. To encompass the entire journey of melanoma care, the latest developments in palliative care, including spiritual care, will be discussed.

Dr. Patricia Tai
Guest Editor

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Keywords

  • melanoma
  • clinical management
  • targeted therapy
  • immunotherapy
  • BRAF inhibitors
  • PD-1 blockade
  • predictive biomarkers
  • treatment resistance
  • combination therapy
  • liquid biopsy

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Published Papers (1 paper)

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Review

18 pages, 560 KB  
Review
Melanoma in Primary Care: A Narrative Review of Training Interventions and the Role of Telemedicine in Medical Education
by Ignazio Stanganelli, Edoardo Mora, Debora Cantagalli, Serena Magi, Laura Mazzoni, Matelda Medri, Cesare Massone, Davide Melandri, Federica Zamagni, Ines Zanna, Gianluca Pistore, Saverio Caini, Salvatore Amato, Vincenzo De Giorgi, Pietro Quaglino, Maria Antonietta Pizzichetta, Giovanni Luigi Tripepi, Giorgia Ravaglia and Sofia Spagnolini
Curr. Oncol. 2025, 32(9), 522; https://doi.org/10.3390/curroncol32090522 - 18 Sep 2025
Abstract
General practitioners play a crucial role in the early detection and prevention of cutaneous melanoma. However, structured training on skin cancer diagnosis and management is often lacking. This narrative review aims to map the current educational interventions for general practitioners focused on melanoma, [...] Read more.
General practitioners play a crucial role in the early detection and prevention of cutaneous melanoma. However, structured training on skin cancer diagnosis and management is often lacking. This narrative review aims to map the current educational interventions for general practitioners focused on melanoma, assess their methodological approaches and outcomes, and explore the contribution of e-learning and telemedicine in medical education. A comprehensive literature search identified 54 relevant studies published between 1 January 1995 and 31 December 2024. Data were extracted and categorized by topics covered, training methodology, interactivity, and clinical outcomes. Training programs varied widely in duration, delivery, and content. Interventions that integrated dermoscopy and interactive methodologies demonstrated improved diagnostic accuracy and clinical impact. E-learning, particularly asynchronous models, emerged as a flexible and effective modality, although few studies evaluated long-term retention or clinical practice changes. Educational programs tailored to general practitioners and enriched with dermoscopy and telemedicine tools show promise in improving melanoma detection and care. Structured, interactive, and blended/hybrid learning models should be prioritized to support effective primary and secondary prevention. Full article
(This article belongs to the Special Issue Advances in Melanoma: From Pathogenesis to Personalized Therapy)
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