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Complications

Complications (ISSN 2813-4966) is an international, peer-reviewed, open access journal on the prevention, diagnosis, etiology, and management of complications in all aspects of basic, translational, and clinical research, as well as epidemiology.
The journal seeks to offer best practices and expert experience, and recommendations on intra-operative and post-operative adverse events, published quarterly online by MDPI.

All Articles (42)

Complications Associated with Ileal Conduit: A Narrative Review

  • Laura Karina Fumero,
  • Luis G. Medina and
  • Federico Eskenazi
  • + 5 authors

Introduction: Rerouting urine flow is often required following radical cystectomy (RC). In this context, the ileal conduit (IC) has become the most common technique for urinary diversion, primarily due to its technical simplicity and suitability for patients with compromised renal function, elderly individuals, and those unable to perform self-catheterization. Objective: This review aims to highlight the complications of IC and categorize them into metabolic and surgical complications, further subdivided by timing (intraoperative, short-term, intermediate-term, and long-term) and anatomical location (uretero-ileal anastomosis, stoma, and ileal segment). Methods: A comprehensive narrative review was conducted to summarize the most common complications of IC, their clinical presentation, and management using Google Scholar, PubMed, and Embase databases to identify studies published from 1950 to 2024. Results: The morbidity associated with IC, especially when compared to continent diversions, remains a subject of debate. Notably, IC-related complications have been described with an incidence rate ranging from 39% to 67%. Conclusions: Providing a comprehensive overview of IC complications and management strategies can enhance clinical practice and improve patient outcomes.

18 November 2025

Ileal segment length and anatomical site for division.

Ankle fractures are extremely common and often require surgical management, historically with open reduction and internal fixation (ORIF), although fibular intramedullary nailing (IMN) has demonstrated promising results in recent years. The purpose of this study is to report on risk factors, quality of reduction, and complications in a series of patients undergoing fibular IMN for management of ankle fractures using a novel device via a retrospective case series. Patients undergoing locked fibular IMN with the Flex-Thread nail (Conventus Flower Orthopedics, Horsham, PA, USA) by a single surgeon from January 2023 to March 2025 were included, with at least 6 months of follow-up. Demographics, comorbidities, injury characteristics, reduction quality, and post-operative complications were recorded. Descriptive analyses were reported for categorical variables. A total of 15 patients were included, with a mean age of 58.9 ± 22.0 (range 18–91) and mean BMI of 31.5 ± 5.7 kg/m2. All patients experienced a fall as their mechanism of injury, with 12 Weber B and 3 Weber C fractures. The mean time to surgery from the date of injury was 9.5 ± 5.5 days. Of 15 patients, 66.7% had good reduction quality, 26.7% had fair, and 1 patient experienced poor reduction quality requiring subsequent hardware removal. There was one patient who experienced delayed wound healing. Patients undergoing fibular fixation using the novel Flex-Thread nail experience a fair to good quality of reduction, with limited complications. Both young and elderly patients have relatively positive early post-operative outcomes. Additional research with longer-term follow-up will be required to confirm its efficacy.

17 November 2025

This study analyzed complication rates, perioperative metrics, and hospital readmissions across BMI cohorts in patients undergoing direct anterior approach (DAA) total hip arthroplasty (THA) in a mature hip practice. Currently, the precise BMI cutoff points for risk in THA are not fully understood. A retrospective review was conducted of patients who underwent DAA THA by a single, highly experienced, fellowship-trained surgeon between January 2021 and January 2023. The use of single-surgeon cases allows for control of many potentially confounding variables but may limit the generalizability of the findings. Data collected included patient demographics, hospital readmissions, 12-month complication rates, and intraoperative metrics. Patients with Class II obesity (BMI 35–39.9) kg/m2 and Class I obesity (BMI 30–34.9) kg/m2 had significantly higher intraoperative blood loss and longer operative times compared to the control group (BMI 20–24.9 kg/m2). No statistically significant differences in hospital readmission rates or complication rates were observed between BMI cohorts. Higher BMI was associated with increased intraoperative blood loss and longer operation time; however, no differences were found in hospital readmissions or complication rates between BMI cohorts.

3 November 2025

  • Systematic Review
  • Open Access

Diabetic foot ulcers drive non-traumatic lower-limb amputation; limb salvage surgery is often pursued to preserve function and survival. Predictors of adverse outcomes remain incompletely defined, and evidence for multidisciplinary team (MDT) care is heterogeneous. We aimed to clarify risk factors for major amputation and death after diabetic limb salvage and evaluate MDT impact. We systematically reviewed 49 studies (2020–2025) reporting major amputation or mortality after limb salvage in diabetes (PROSPERO CRD420251044859). Risk factors spanned demographic, clinical, and surgical domains (e.g., older age, male sex, renal/cardiovascular disease, ischemia, osteomyelitis, advanced ulcer classification). MDT models generally showed lower amputation rates and improved wound healing, with occasional survival benefits; heterogeneity precluded meta-analysis. As a real-world comparator, the Mid Essex Diabetes Amputation Reduction Plan (MEDARP) treated 72 high-risk patients using a “toe and flow” MDT. Major amputation occurred in 6.9% and mortality in 12.5%, both at or below published ranges, with gains in patient-reported outcomes. Findings support MDT-based strategies, but conclusions should be interpreted cautiously given the predominantly observational evidence, and highlight the need for standardized outcome definitions and reporting.

22 October 2025

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Complications - ISSN 2813-4966