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Coatings
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Polymer Coatings for Biomaterials
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Polymer Coatings for Biomaterials

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Bioactive Coatings and Biointerfaces".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 14991

Special Issue Editor

Prof. Dr. Renáta Oriňáková

E-Mail Website1 Website2
Guest Editor
Department of Physical Chemistry, Institute of Chemistry, Faculty of Science, P.J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovak Republic
Interests: biomaterials; corrosion; coatings; electrochemistry; biosensors

Special Issue Information

Dear Colleagues,

Biomaterials are widely used in current medical practice to replace or repair diseased tissue. Based on their chemical composition, they can be metals, ceramics, polymers or composites. In addition to permanent medical implants, biodegradable materials have gained substantial interest from the medical and material engineering community. Current advancements in many different fields have enabled fabrication of novel biomaterials and their modification with the aim to produce ideal implantable medical devices that possess the clinical requirements and are able to improve the wellness and health of human beings through restoration or implementation of body functions.

Metals are the most commonly used biomaterials because of their outstanding mechanical properties, but combinations of different types of materials have also demonstrated promising applications as biomedical materials.

The biocompatibility of implant surface is of specific interest since the surface of biomedical devices is in direct contact with the living organism. Hence, many scientists are focusing on the modification of the surface of the biomaterial in order to improve its biocompatibility and obtain desirable properties.

Polymeric materials can be synthesized through various production routes and show a wide range of physical and chemical properties. Innovative polymer coatings have demonstrated the ability to yield the desired structure, enhance mechanical properties, accelerate degradation rate, adjust bioactivity, and improve biocompatibility of biomedical materials. Surface modification through the creation of a polymer coating layer represents a promising way of design and development of new adaptive and functional biomaterials.

This Special Issue aims to present a complex overview of the recent developments and challenges in the production methods, functions, structures, properties, and applications of polymer coatings for biomaterials. Original research papers and review articles are welcomed.

Potential topics include but are not limited to the following:

Polymer coatings for permanent implants;
Polymer coatings for biodegradable biomaterials;
Production methods of polymer coatings for biomaterials;
Functionality and characterizations of polymer coatings for biomaterials;
Polymer coatings for the adjustment of mechanical properties of biomaterials;
Polymer coatings for the adjustment of corrosion bahaviour of biomaterials;
Polymer coatings for the adjustment of biocompatibility of biomaterials;
Polymer coatings for the adjustment of bioactivity of biomaterials;
Polymer coatings for the adjustment of surface proteins or cells interactions of the surface of biomaterials.

Prof. Dr. Renáta Oriňáková
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer coatings for permanent implants
  • polymer coatings for biodegradable biomaterials
  • production methods of polymer coatings for biomaterials
  • functionality and characterizations of polymer coatings for biomaterials
  • bioactive polymer coating for biomaterials

Published Papers (5 papers)

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Research

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17 pages, 3356 KiB  
Article
Adhesion between Biocomposites and Different Metallic Structures Additive Manufactured
by Stanca Cuc, Alexandru Burde, Cosmin Cosma, Dan Leordean, Mircea Rusu, Nicolae Balc, Doina Prodan, Marioara Moldovan and Razvan Ene
Coatings 2021, 11(4), 483; https://doi.org/10.3390/coatings11040483 - 20 Apr 2021
Cited by 2 | Viewed by 2122
Abstract
This study was concerned with the adhesion of resin cement to metal surfaces obtained by selective laser melting process (SLM), and how it could be improved the bond strength at the biocomposite-metal junction. The SLM substrates were manufactured out of pure titanium (Ti), [...] Read more.
This study was concerned with the adhesion of resin cement to metal surfaces obtained by selective laser melting process (SLM), and how it could be improved the bond strength at the biocomposite-metal junction. The SLM substrates were manufactured out of pure titanium (Ti), Ti6Al7Nb, and CoCr alloys. The metallic surfaces were covered with 5 types of biocomposites: 2 commercially resin-modified glass-ionomer cements (GC Fuji Plus and KETAC CEM) and 3 types of in-house developed materials. These biocomposites were mechanical characterized under compression and bending trials. The biocomposites-metal adhesion was settled both on as built metallic surfaces and after they were sandblasted with alumina. All the sandblasted SLM surfaces presented higher adhesion strength in comparison with the untreated specimens. The CoCr specimens show the highest bonding value. Additionally, the morphological aspects of joining interfaces were investigated using a scanning electron microscope (SEM). The mechanical properties and metal adhesion of these biocomposites were influenced by the liquid powder ratio. It is essential to apply a surface treatment on SLM substrate to achieve a stronger bond. Also, the chemical composition of biocomposite is a major factor which may improve the adhesion of it on different metallic substrates. Full article
(This article belongs to the Special Issue Polymer Coatings for Biomaterials)
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17 pages, 7339 KiB  
Article
Nonthermal Plasma Treatment Improves Uniformity and Adherence of Cyclodextrin-Based Coatings on Hydrophobic Polymer Substrates
by Greg D. Learn, Emerson J. Lai and Horst A. von Recum
Coatings 2020, 10(11), 1056; https://doi.org/10.3390/coatings10111056 - 31 Oct 2020
Cited by 10 | Viewed by 2536
Abstract
Low surface energy substrates, which include many plastics and polymers, present challenges toward achieving uniform, adherent coatings, thus limiting intended coating function. These inert materials are common in various applications due to favorable bulk, despite suboptimal surface, properties. The ability to functionally coat [...] Read more.
Low surface energy substrates, which include many plastics and polymers, present challenges toward achieving uniform, adherent coatings, thus limiting intended coating function. These inert materials are common in various applications due to favorable bulk, despite suboptimal surface, properties. The ability to functionally coat low surface energy substrates holds broad value for uses across medicine and industry. Cyclodextrin-based materials represent an emerging, widely useful class of coatings, which have previously been explored for numerous purposes involving sustained release, enhanced sorption, and reversible reuse thereof. In this study, substrate exposure to nonthermal plasma was explored as a novel means to improve uniformity and adherence of cyclodextrin-based polyurethane coatings upon unreceptive polypropylene substrates. Plasma effects on substrates were investigated using contact angle goniometry and X-ray photoelectron spectroscopy (XPS). Plasma impact on coating uniformity was assessed through visualization directly and microscopically. Plasma effects on coating adhesion and bonding were studied with mechanical lap-shear testing and XPS, respectively. Substrate surface wettability and oxygen content increased with plasma exposure, and these modifications were associated with improved coating uniformity, adhesion, and interfacial covalent bonding. Findings demonstrate utility of, and elucidate mechanisms behind, plasma-based surface activation for improving coating uniformity, adherence, and performance on inert polymeric substrates. Full article
(This article belongs to the Special Issue Polymer Coatings for Biomaterials)
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17 pages, 1952 KiB  
Article
New Antimicrobial Biomaterials for the Reconstruction of Craniofacial Bone Defects
by Andreea Elena Miron (Lungu), Marioara Moldovan, Cristina Alexandra Prejmerean, Doina Prodan, Mihaela Vlassa, Miuța Filip, Mîndra Eugenia Badea and Mădălina Anca Moldovan
Coatings 2020, 10(7), 678; https://doi.org/10.3390/coatings10070678 - 15 Jul 2020
Cited by 1 | Viewed by 2393
Abstract
Reconstructive bone surgery of the head and neck could prove challenging in terms of postoperative healing and recovery. Fighting infection during the healing period is one of the critical factors of the long-term survival of an implant. The aim of the study was [...] Read more.
Reconstructive bone surgery of the head and neck could prove challenging in terms of postoperative healing and recovery. Fighting infection during the healing period is one of the critical factors of the long-term survival of an implant. The aim of the study was to develop an innovative composition suitable for an antibacterial craniofacial implant that should have the capacity to continuously and constantly release the amount of gentamicin necessary to prevent the post-surgical infections. For this purpose, a series of composite materials based on dimethacrylic monomers, hydroxyapatite and ZrO2, with (series B) or without the addition of polymethyl methacrylate (series A), reinforced with woven E-glass fibers (FRC) were obtained using the laminate lay-up process. Gentamicin was included in all FRC sample matrices to confer an antimicrobial effect. The results show that after extraction of the residual monomers from the FRC samples in different solvents (chloroform, acetone and ethyl alcohol), the cumulative amount of released gentamicin after 12 days was between 7.05–11.38 mg for A samples and 11.21–14.52 mg for B samples. The microbiological protocol showed that gentamicin induces a two weeks-lasting antimicrobial effect maintained over the minimal inhibitory concentration for P. aeruginosa and S. aureus. Full article
(This article belongs to the Special Issue Polymer Coatings for Biomaterials)
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13 pages, 2457 KiB  
Article
Chitosan-Functionalized Mg0.5Co0.5Fe2O4 Magnetic Nanoparticles Enhance Delivery of 5-Fluorouracil In Vitro
by Sanele Mngadi, Seipati Mokhosi, Moganavelli Singh and Wendy Mdlalose
Coatings 2020, 10(5), 446; https://doi.org/10.3390/coatings10050446 - 02 May 2020
Cited by 11 | Viewed by 2574
Abstract
Magnetic nanoparticles (MNPs) have been widely investigated as a strategy to improve the delivery efficiency of therapeutic and diagnostic agents. Substituted iron oxides or ferrite nanoparticles (NPs) such as CoFe2O4 represent an interesting and novel class of MNPs, although they [...] Read more.
Magnetic nanoparticles (MNPs) have been widely investigated as a strategy to improve the delivery efficiency of therapeutic and diagnostic agents. Substituted iron oxides or ferrite nanoparticles (NPs) such as CoFe2O4 represent an interesting and novel class of MNPs, although they are under-researched in the field of biomedicine. In this study, chitosan-functionalized Mg0.5Co0.5Fe2O4 NPs were loaded with the anti-cancer 5-fluorouracil (5-FU) drug to yield CS-Mg0.5Co0.5Fe2O4-5FU. Transmission electron microscopy (TEM), Fourier Transform infra-red (FTIR) spectroscopy and nanoparticle tracking analysis (NTA) were employed to determine the physiochemical properties of the NPs. Physico-chemical characterizations confirmed spherical NPs with particle sizes of approximately 20.39 nm. Improved colloidal stability was observed, as determined by a zeta potential of approximately −20 mV for the drug-loaded CS-Mg0.5Co0.5Fe2O4 NPs. Drug encapsulation efficiencies of >60% were attained, showing a pH-dependent release of 5-FU. Cell viabilities investigated using the 3-[(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] (MTT) and sulforodhamine B (SRB) assays in human embryonic kidney (HEK293), human breast adenocarcinoma (MCF-7) and human cervical cancer (HeLa) cells showed that these drug-loaded NPs exhibited more targeted tumor-specific cytotoxicities compared to free drugs. CS-Mg0.5Co0.5Fe2O4-5-FU NPs displayed significant targeted delivery potential to the investigated cancer cell lines. Conclusively, these results suggest that the CS-Mg0.5Co0.5Fe2O4-5-FU NPs are promising therapeutic delivery systems in anti-cancer treatment. Full article
(This article belongs to the Special Issue Polymer Coatings for Biomaterials)
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Review

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32 pages, 6532 KiB  
Review
Surface Modifications of Biodegradable Metallic Foams for Medical Applications
by Renáta Oriňaková, Radka Gorejová, Zuzana Orságová Králová and Andrej Oriňak
Coatings 2020, 10(9), 819; https://doi.org/10.3390/coatings10090819 - 24 Aug 2020
Cited by 22 | Viewed by 4414
Abstract
Significant progress was achieved presently in the development of metallic foam-like materials improved by biocompatible coatings. Material properties of the iron, magnesium, zinc, and their alloys are promising for their uses in medical applications, especially for orthopedic and bone tissue purposes. Current processing [...] Read more.
Significant progress was achieved presently in the development of metallic foam-like materials improved by biocompatible coatings. Material properties of the iron, magnesium, zinc, and their alloys are promising for their uses in medical applications, especially for orthopedic and bone tissue purposes. Current processing technologies and a variety of modifications of the surface and composition facilitate the design of adjusted medical devices with desirable mechanical, morphological, and functional properties. This article reviews the recent progress in the design of advanced degradable metallic biomaterials perfected by different coatings: polymer, inorganic ceramic, and metallic. Appropriate coating of metallic foams could improve the biocompatibility, osteogenesis, and bone tissue-bonding properties. In this paper, a comprehensive review of different coating types used for the enhancement of one or several properties of biodegradable porous implants is given. An outline of the conventional preparation methods of metallic foams and a brief overview of different alloys for medical applications are also provided. In addition, current challenges and future research directions of processing and surface modifications of biodegradable metallic foams for medical applications are suggested. Full article
(This article belongs to the Special Issue Polymer Coatings for Biomaterials)
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