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Advanced Materials for Highly Biocompatible Hydrogel Systems
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Advanced Materials for Highly Biocompatible Hydrogel Systems

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 6748

Special Issue Editor

Dr. Zheng Zhao

E-Mail Website
Guest Editor
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
Interests: biomaterials; tissue engineering; hydrogels; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels are three-dimensional (3D) networks based on crosslinked hydrophilic polymers. Owing to their high water content, good biocompatibility, and elasticity similar to that of native tissue, hydrogels have gained increasing attraction as promising biomaterials for mimicking the extracellular matrix and use in biomedical applications such as drug delivery and tissue engineering. Hydrogels can exhibit tunable physicochemical characteristics based on well-studied preparation methods, properties, and modification strategies. However, the lack of multifunctionality and poor mechanical properties of previously developed hydrogels may limit their application. In addition, traditional preformed hydrogels may cause considerable inconvenience to patients since they need be implanted subcutaneously. To solve this problem, injectable hydrogels have been developed that undergo a sol-to-gel transition in response to external stimuli before and after injection into the body . One of the most commonly used injectable hydrogels are thermosensitive hydrogels. These stimuli-responsive hydrogels have recently attracted much attention because they can be engineered to be responsive to external stimuli, such as temperature, pH, light, electric field, and specific chemical and molecules.

We warmly invite you to submit your recent work to this Special Issue on “Advanced Materials for Highly Biocompatible Hydrogel Systems”.

Specific topics of interest include but are not limited to:

  • Synthesis of biocompatible hydrogels
  • Modification of biocompatible hydrogels
  • Injectable hydrogels
  • Self-healing hydrogels
  • Multifunctional hydrogels
  • Stimuli-responsive hydrogels 
  • Hydrogel coatings of biomaterials

Prof. Dr. Zheng Zhao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Editorial

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5 pages, 181 KiB  
Editorial
Advanced Materials for High Biocompatible Hydrogel System
by Guanlin Li and Zheng Zhao
Coatings 2022, 12(9), 1357; https://doi.org/10.3390/coatings12091357 - 17 Sep 2022
Cited by 4 | Viewed by 1773
Abstract
Hydrogels are gels with water as the dispersion medium and three-dimensional porous polymer networks cross-linked chemically or physically [...] Full article
(This article belongs to the Special Issue Advanced Materials for Highly Biocompatible Hydrogel Systems)

Research

Jump to: Editorial

12 pages, 2713 KiB  
Article
The Initial Development and Evaluation of Cross-Linked Casein Films for Sustainable Footwear
by Liliana Indrie, Steven McNeil, Mehmet Mete Mutlu, Sanda Bota, Dorina Camelia Ilieș and Hüseyin Ata Karavana
Coatings 2023, 13(2), 217; https://doi.org/10.3390/coatings13020217 - 17 Jan 2023
Cited by 2 | Viewed by 2425
Abstract
To increase the sustainability of footwear and align it with the circular bioeconomy, there is a pressing need to develop novel bio-based materials to replace the synthetic polymers currently used. In this study, casein-based films were prepared by solution casting with a tannic [...] Read more.
To increase the sustainability of footwear and align it with the circular bioeconomy, there is a pressing need to develop novel bio-based materials to replace the synthetic polymers currently used. In this study, casein-based films were prepared by solution casting with a tannic acid cross-linker, and a glycerol plasticizer. The properties important to footwear materials were characterised, including tensile strength and elongation, stitch strength, hardness, grain cracking strength, water vapour permeability, and thermal properties. The tannic acid imparted a brown colour to the films with good resistance to light-induced fading. Their tensile strengths were 4–5 N/mm2, elongation at break 45%–73%, and water vapour permeability 0.2–0.6 mg/(cm2h), depending upon the levels of the cross-linker and plasticiser. The strength of the films was close to those of some non-leather footwear materials such as compact rubbers and insock materials, but below that required for leather shoe vamps/uppers. The casein films were successfully used in sneaker- and ballerina-style shoes as components of the insock and decorative design elements on the vamp. This work has demonstrated the concept of using casein films in footwear. The properties of the films could be improved by further research, particularly with respect to cross-linking, plasticizing, and combining with bio-based fibers and fabrics. Full article
(This article belongs to the Special Issue Advanced Materials for Highly Biocompatible Hydrogel Systems)
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21 pages, 21178 KiB  
Article
Verification of the Influence of the 2-Hydroxy-2-methylpropiophenone (Photoinitiator) Content in Hydrogel Materials on Their Physicochemical Properties and Surface Morphology
by Magdalena Kędzierska, Sonia Kudłacik-Kramarczyk, Mateusz Jamroży, Magdalena Bańkosz, Janusz Walter, Piotr Potemski and Anna Drabczyk
Coatings 2023, 13(1), 40; https://doi.org/10.3390/coatings13010040 - 26 Dec 2022
Cited by 1 | Viewed by 2196
Abstract
Currently, hydrogel materials are being widely developed and investigated. Factors affecting their properties may be mentioned, such as the types and the amounts of the reagents used for the synthesis of the hydrogel matrix and modifiers; thus, the main aim of the investigations [...] Read more.
Currently, hydrogel materials are being widely developed and investigated. Factors affecting their properties may be mentioned, such as the types and the amounts of the reagents used for the synthesis of the hydrogel matrix and modifiers; thus, the main aim of the investigations was to check the impact of the amount of photoinitiator applied during the UV-induced polymerization of polyvinylpyrrolidone-based hydrogels incorporated with vitamin C and Aloe vera juice. The experiments that were performed were focused on determining the hydrogels’ swelling capability, behavior in simulated body fluids, hydrophilicity, chemical structure (using FT-IR spectroscopy), as well as their surface morphology and roughness. It was proven that developed materials had relatively rough surfaces, they did not degrade in simulated physiological liquids, and their swelling ratios in these media were 2.0–3.0 g/g. The only change in the pH of the incubation media—a slight decrease—was caused by the release of the modifiers into the tested liquids. Subsequently, it was demonstrated that as the amount of the photoinitiator (2-hydroxy-2-methylpropiophenone) increased, the percentage elongation decreased, and the tensile strength increased. The content of the photoinitiator in the hydrogels also influenced their wettability. All samples showed hydrophilicity; the more photoinitiator in the hydrogel structure, the lower wetting angle for water. Moreover, the greater the amount of 2-hydroxy-2-methylpropiophenone, the smoother and more homogeneous the hydrogel surface; thus, considering the demonstrated physicochemical properties of developed materials, they seem to show application potential for more advanced research regarding the development of innovative dressing materials. Full article
(This article belongs to the Special Issue Advanced Materials for Highly Biocompatible Hydrogel Systems)
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14 pages, 34137 KiB  
Article
Supercritical Fluid-Assisted Fabrication of PDA-Coated Poly (l-lactic Acid)/Curcumin Microparticles for Chemo-Photothermal Therapy of Osteosarcoma
by Zheng Zhao, Shilu Chen, Yao Xiao, Maobin Xie and Wen Yu
Coatings 2022, 12(4), 524; https://doi.org/10.3390/coatings12040524 - 13 Apr 2022
Cited by 4 | Viewed by 2333
Abstract
After traditional osteosarcoma resection, recurrence of tumor is still a major clinical challenge. The combination of chemotherapy and photothermal therapy (PTT) has great potential in improving therapeutic effect. However, the studies using polydopamine (PDA) as photothermal transducing agent to improve the anti-cancer activity [...] Read more.
After traditional osteosarcoma resection, recurrence of tumor is still a major clinical challenge. The combination of chemotherapy and photothermal therapy (PTT) has great potential in improving therapeutic effect. However, the studies using polydopamine (PDA) as photothermal transducing agent to improve the anti-cancer activity of curcumin (CM)-loaded poly (l-lactic acid) (PLLA) microparticles (PLLA/CM) have seldom been investigated. In this study, we reported the synthesis of PDA-coated PLLA/CM microparticles (PDA-PLLA/CM) prepared by PDA coating on the surface of the PLLA/CM microparticles fabricated by solution-enhanced dispersion by supercritical CO2 (SEDS) for chemo-photothermal therapy of osteosarcoma. The average particle sizes of PLLA/CM and PDA-PLLA/CM microparticles with a spherical shape were (802.6 ± 8.0) nm and (942.5 ± 39.5) nm, respectively. PDA-PLLA/CM microparticles exhibited pH- and near-infrared (NIR)-responsive release behavior to promote CM release in the drug delivery system. Moreover, PDA-PLLA/CM microparticles displayed good photothermal conversion ability and photothermal stability attributed to PDA coating. Additionally, the results of in vitro anti-cancer experiment showed that 500 μg/mL PDA-PLLA/CM microparticles had good anti-cancer effect on MG-63 cells and no obvious toxicity to MC3T3-E1 cells. After incubation with PDA-PLLA/CM microparticles for 2 days, NIR irradiation treatment improved the anti-cancer activity of PDA-PLLA/CM microparticles obviously and reduced the cell viability of osteosarcoma from 47.4% to 20.6%. These results indicated that PDA-PLLA/CM microparticles possessed a synergetic chemo-photothermal therapy for osteosarcoma. Therefore, this study demonstrated that PDA-PLLA/CM microparticles may be an excellent drug delivery platform for chemo-photothermal therapy of tumors. Full article
(This article belongs to the Special Issue Advanced Materials for Highly Biocompatible Hydrogel Systems)
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