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Gels
Special Issues
Recent Advances in Hydrogels for Wound Healing
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Recent Advances in Hydrogels for Wound Healing

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 1981

Special Issue Editors

Dr. Haiyong Ao

E-Mail Website
Guest Editor
Jiangxi Key Laboratory of Nanobiomaterials, School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China
Interests: biomaterials; wound healing; hydrogel
Dr. Botao Song

E-Mail Website
Guest Editor
College of Chemistry and Materials Science, Northwest University China, Xi'an 710069, China
Interests: biomaterials; tissue engineering; hydrogel
Prof. Dr. Jinshan Guo

E-Mail Website
Guest Editor
Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Interests: biomaterials; regenerative medicine; tissue engineering; bone regeneration; tissue adhesives
Dr. Zheng Zhao

E-Mail Website
Guest Editor
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
Interests: biomaterials; tissue engineering; hydrogels; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels for wound healing have attracted much attention in recent decades. Hydrogel is a three-dimensional network structure polymer gel with similar structural characteristics to extracellular matrix and adjustable physical and chemical properties. Hydrogel-based dressings exhibit excellent gas permeability, high water absorbency and favorable biocompatibility. In particular, hydrogels can be further functionalized by compounding functional substances and forming functional hydrogel dressings that meet clinical needs.

This Special Issue on “Recent Advances in Hydrogels for Wound Healing” is dedicated to recent developments in the design, properties and mechanism of hydrogels for wound healing. We invite experts to contribute to this research topic to discuss the improvements in the design and fabrication of novel hydrogels and explore the potential of hydrogels for wound healing. Publication of original research articles, rapid communications or reviews in this Special Issue will make an important contribution to developing hydrogel-based dressing.

Dr. Haiyong Ao
Dr. Botao Song
Prof. Dr. Jinshan Guo
Dr. Zheng Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • polymers
  • wound healing
  • dressing
  • functionalization

Published Papers (1 paper)

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Research

20 pages, 10831 KiB  
Article
Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing
by Irina Popescu, Marieta Constantin, Gheorghe Solcan, Daniela Luminita Ichim, Delia Mihaela Rata, Loredana Horodincu and Carmen Solcan
Gels 2023, 9(8), 654; https://doi.org/10.3390/gels9080654 - 14 Aug 2023
Cited by 3 | Viewed by 1581
Abstract
The wound healing process is often slowed down as a result of complications from bacterial infections and inflammatory reactions. Therefore, it is necessary to develop dressings with fast antibacterial and anti-inflammatory activity that shorten the wound healing period by promoting cell migration and [...] Read more.
The wound healing process is often slowed down as a result of complications from bacterial infections and inflammatory reactions. Therefore, it is necessary to develop dressings with fast antibacterial and anti-inflammatory activity that shorten the wound healing period by promoting cell migration and proliferation. Chitosan (CS)-based hydrogels have been widely studied for their antibacterial and wound healing capabilities. Herein, we developed a composite hydrogel based on CS and PVA embedding silver nanoparticles (AgNPs) with antibacterial properties and ibuprofen (Ib) as an anti-inflammatory agent. The hydrogel prepared by double physical cross-linking, with oxalic acid and by freeze–thawing, loaded with 0.225 wt.% AgNPs and 0.264 wt.% Ib, displayed good mechanical properties (compressive modulus = 132 kPa), a high swelling degree and sustained drug delivery (in simulated skin conditions). Moreover, the hydrogel showed strong antibacterial activity against S. aureus and K. pneumoniae due to the embedded AgNPs. In vivo, this hydrogel accelerated the wound regeneration process through the enhanced expression of TNF alpha IP8, by activating downstream cascades and supporting the healing process of inflammation; Cox2, which enhances the migration and proliferation of cells involved in re-epithelization and angiogenesis; MHCII, which promotes immune cooperation between local cells, eliminating dead tissue and controlling infection; the intense expression of Col I as a major marker in the tissue granulation process; and αSMA, which marks the presence of myofibroblasts involved in wound closure and indicates ongoing re-epithelization. The results reveal the potential healing effect of CS/PVA/AgNPs/Ib hydrogels and suggest their potential use as wound dressings. Full article
(This article belongs to the Special Issue Recent Advances in Hydrogels for Wound Healing)
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