Molecular Mechanisms and Biomarkers in Asthma: From MicroRNA to Immune Modulation
A Special Issue of Current Issues in Molecular Biology (ISSN 1467-3045) belonging to the section "Molecular Medicine".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 1748
Editor
Special Issue Information
Dear Colleagues,
Asthma is a heterogeneous chronic airway disease characterized by complex interactions between genetic susceptibility, environmental exposures, and immune dysregulation. Despite major advances in clinical management, significant gaps remain in understanding the molecular mechanisms underlying disease onset, progression, severity, and treatment response. This Special Issue aims to provide an updated and comprehensive overview of the molecular pathways and biomarkers involved in asthma, with particular emphasis on epigenetic regulation, microRNAs, immune cell modulation, and inflammatory signaling networks. Special attention will be given to microRNA-mediated regulatory circuits acting across different cellular compartments, including airway epithelium, immune cells, and extracellular vesicles, as well as their potential role as biomarkers.
We welcome original research articles, high-quality reviews, and case series addressing mechanistic insights from experimental, translational, and clinical studies. Topics of interest include, but are not limited to, the role of microRNAs and other non-coding RNAs in airway inflammation and remodeling; immune-endotype characterization; biomarkers for diagnosis, prognosis, and therapeutic stratification; gene–environment interactions related to occupational and environmental exposures, air pollution, and oxidative stress; and emerging targets for personalized and precision medicine in asthma. Well-characterized clinical case series highlighting rare phenotypes, complex disease presentations, or translational biomarker findings are particularly encouraged. By integrating molecular biology, immunology, environmental medicine, and clinical perspectives, this Special Issue seeks to advance current knowledge and promote innovative approaches for improved disease phenotyping and management.
Dr. Filippo Liviero
Guest Editor
Manuscript Submission Information
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Keywords
- asthma
- microRNAs
- immune modulation
- epigenetics
- biomarkers
- environmental and occupational exposure
- airway inflammation
- precision medicine
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