Molecular and Cellular Mechanisms of Epilepsy: Integrative Multi-Omics, Spatial Biology, and Computational Approaches
A Special Issue of Current Issues in Molecular Biology (ISSN 1467-3045) belonging to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 April 2027 | Viewed by 5
Editors
Interests: amyotrophic lateral sclerosis; Alzheimer’s disease; epilepsy; multiple sclerosis; Parkinson’s disease; stroke; metabolomics; mass spectrometry; magnetic nuclear resonance; antiseizure medication; 1H nuclear magnetic resonance; focal epilepsy; response to treatment
Interests: epilepsy; epileptogenesis; molecular and cellular neuroscience; single-cell; transcriptomics; epigenomics; multi-omics; spatial biology; spatial omics; computational biology; systems biology
Special Issue Information
Dear Colleagues,
Epilepsy is a complex neurological disorder shaped by molecular, cellular, and network-level alterations in the brain. Although genetic, cellular, and physiological studies have advanced the field, important gaps remain in explaining how molecular alterations contribute to epileptogenesis, tissue pathology, disease progression, and treatment response. A central challenge is to connect molecular and cellular changes across biological scales while preserving their anatomical and pathological context.
Recent advances in multi-omics, spatial biology, single-cell technologies, and computational approaches are providing unprecedented opportunities to investigate these mechanisms. By integrating transcriptomic, proteomic, metabolomic, epigenomic, and other molecular layers with spatial and cell-type-specific information, these approaches can reveal disease-associated pathways, cellular interactions, molecular heterogeneity, and tissue-specific alterations that may not be captured by individual molecular or cellular analyses. Spatially resolved approaches are particularly valuable for understanding how molecular and cellular changes are geographically organized within epileptic tissue and how they relate to pathological features and functional alterations.
This Special Issue highlights recent advances in the cellular and molecular mechanisms underlying epilepsy, with emphasis on studies that integrate multi-omics, spatial biology, single-cell technologies, and computational or systems-level analyses. Relevant contributions may address epileptogenesis, neuronal and glial dysfunction, synaptic alterations, neuroinflammation, metabolism, cell–cell interactions, network dysfunction, disease progression, and mechanisms of treatment resistance.
We encourage interdisciplinary submissions that link molecular and cellular data to anatomical, neuropathological, or clinically relevant information. Studies examining heterogeneity across patients, brain regions, tissue compartments, disease etiologies, or pathological stages are also welcome, particularly when they identify biologically meaningful biomarkers, molecular signatures, pathways, or therapeutic targets.
Suggested themes include, but are not limited to, the following:
- Molecular and cellular mechanisms underlying epileptogenesis and epilepsy progression;
- Cell-type-specific molecular alterations in neuronal and glial populations;
- Synaptic, metabolic, inflammatory, and signaling mechanisms contributing to epilepsy;
- Neuron–glia interactions and cell–cell communication in epileptic tissue;
- Integrative multi-omics approaches, including transcriptomics, proteomics, metabolomics, lipidomics, epigenomics, and their integration;
- Spatial transcriptomics, spatial proteomics, spatial metabolomics, and other spatially resolved approaches to epilepsy;
- Single-cell and cell-type-specific approaches for characterizing molecular heterogeneity;
- Molecular and cellular signatures associated with neuropathological features and disease phenotypes;
- Computational, network-based, and systems biology approaches for integrating molecular and cellular datasets;
- Molecular mechanisms of treatment resistance and identification of potential therapeutic targets and biomarkers.
Original research articles and reviews are welcome.
We look forward to receiving your contributions.
Dr. Amanda Morato Do Canto
Guest Editor
Dr. Jaqueline Cruz Geraldis
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- epilepsy
- epileptogenesis
- multi-omics
- spatial biology
- single-cell omics
- proteomics
- transcriptomics
- metabolomics
- neuroinflammation
- systems biology
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