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Angiogenesis in Diseases: Molecular Mechanism and Regulation

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1228

Special Issue Editor


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Guest Editor
1. Departamento de Fisiología y Farmacología, Universidad de Salamanca, 37007 Salamanca, Spain
2. Biomedical Research Institute of Salamanca, 37007 Salamanca, Spain
Interests: cardiovascular physiology; cardiovascular pathophysiology; tumor angiogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Angiogenesis is the physiological process of forming new capillaries from existing vasculature and is a key process involved in embryonic development as well as in organ growth and repair. Excessive angiogenesis is directly or indirectly associated with many diseases, including cancer, autoimmune diseases, diabetic retinopathy, rheumatoid arthritis and atherosclerosis. Conversely, insufficient vascularization and insufficient vessel growth can exacerbate or lead to cerebral ischemia, coronary heart disease, and delayed wound healing. In cancer, the relationship between endoglin and tumor angiogenesis has been extensively studied. Anti-angiogenic drugs have been intensively investigated for the treatment of cancer; however, these are ineffective in some cases and often develop resistance.

This Special Issue aims to summarize the current knowledge and cutting-edge research on the molecular mechanisms of angiogenesis. We look forward to receiving valuable contributions from researchers and academics all around the world.

Prof. Dr. Alicia Rodríguez-Barbero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • blood vessels
  • angiogenic factors
  • trophic factors
  • angiogenesis biomarkers
  • cancers
  • heart diseases

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Published Papers (1 paper)

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Review

19 pages, 954 KiB  
Review
Vascular Endothelial Growth Factor Receptors in the Vascularization of Pancreatic Tumors: Implications for Prognosis and Therapy
by Craig Grobbelaar, Vanessa Steenkamp and Peace Mabeta
Curr. Issues Mol. Biol. 2025, 47(3), 179; https://doi.org/10.3390/cimb47030179 - 10 Mar 2025
Cited by 1 | Viewed by 841
Abstract
In pancreatic cancer (PC), vascular endothelial growth factor (VEGF) and its primary receptor, vascular endothelial growth factor receptor (VEGFR)-2, are central drivers of angiogenesis and metastasis, with their overexpression strongly associated with poor prognosis. In some PC patients, VEGF levels correlate with disease [...] Read more.
In pancreatic cancer (PC), vascular endothelial growth factor (VEGF) and its primary receptor, vascular endothelial growth factor receptor (VEGFR)-2, are central drivers of angiogenesis and metastasis, with their overexpression strongly associated with poor prognosis. In some PC patients, VEGF levels correlate with disease stage, tumor burden, and survival outcomes. However, therapies targeting VEGF and VEGFR-2, including tyrosine kinase inhibitors (TKIs) and monoclonal antibodies, have demonstrated limited efficacy, partly due to the emergence of resistance mechanisms. Resistance appears to stem from the activation of alternative vascularization pathways. This review explores the multifaceted roles of VEGFRs in pancreatic cancer, including VEGFR-1 and VEGFR-3. Potential strategies to improve VEGFR-targeting therapies, such as combination treatments, the development of more selective inhibitors, and the use of biomarkers, are discussed as promising approaches to enhance treatment efficacy and outcomes. Full article
(This article belongs to the Special Issue Angiogenesis in Diseases: Molecular Mechanism and Regulation)
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