Molecular Dialogues: Signaling Networks of the Aging Nervous System
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 280
Editor
Interests: neuron–glia communication; calcium signaling; mitochondrial–cytosolic signaling; metabolic control of neural signaling; purinergic signaling; cannabinoid signaling; bioactive lipid mediators; redox signaling; neuroinflammation; neural aging; synaptic maintenance; cell death; neuroprotection; retinal neurobiology
Special Issue Information
Dear Colleagues,
This Special Issue centers on the molecular logic through which the nervous system ages, emphasizing how signaling networks are remodeled over time and how these changes influence neural resilience or vulnerability. The contributions examine age-dependent alterations in intracellular and intercellular communication, focusing on signaling pathways built around ions, neurotransmitters, bioactive lipids, redox mediators, and metabolic intermediates. Special emphasis is placed on calcium handling, mitochondrial–cytosolic crosstalk, and the coupling between energy metabolism and signal transduction. These molecular dialogues regulate synaptic maintenance, neuroglial interactions, stress responses, and decisions governing cellular adaptation, senescence, or death. The issue highlights how cumulative molecular dysregulation, rather than isolated defects, drives functional decline, chronic inflammation, and susceptibility to neurodegeneration during aging. By integrating experimental data with mechanistic and conceptual perspectives, this collection seeks to define core signaling nodes and molecular circuits that shape the aging nervous system, offering a framework for identifying targets capable of modulating neural aging and delaying age-associated neurological disease.
Dr. Hercules Rezende Freitas
Guest Editor
Manuscript Submission Information
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Keywords
- neuroglial signaling
- molecular signal transduction
- calcium dynamics
- bioactive lipids
- neuroinflammation
- neural metabolism
- cell–cell communication
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