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Novel Immunotherapy for Neurological Diseases

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1606

Special Issue Editor


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Guest Editor
Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
Interests: neurodegenerative diseases; neural function; neuroinflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Novel immunotherapeutic approaches for neurological disorders are rapidly evolving in several directions. First, monoclonal antibodies can target specific pathological features, such as beta-amyloid plaques in Alzheimer's disease, to attenuate neuroinflammation. Second, immune checkpoint inhibitors and cellular therapies (e.g., regulatory T cells) aim to enhance the immune system's ability to respond to disease. In addition, cytokine modulation and vaccine development are being explored with the aim of modulating neuroinflammation or inducing immune tolerance. Modulation of the gut microbiome and gene therapy are also seen as potential new therapies. The combination of these approaches may open new pathways for the treatment of neurological diseases and improve the quality of life of patients.

We invite experts to share their valuable insights, new data, and comprehensive systematic evaluations in this emerging and critical field.

Dr. Michel-Edwar Mickael
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • T cells
  • immune
  • neurological disorders
  • Alzheimer's disease

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Published Papers (1 paper)

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Review

17 pages, 313 KiB  
Review
The Struggle Between Chimeric Antigen Receptor T-Cell Therapy and Neurological Complications in Acute Lymphoblastic Leukemia Treatment
by Norwin Kubick, Marzena Łazarczyk, Omar Awad, Michał Ławiński, Jarosław Olav Horbańczuk, Mariusz Sacharczuk, Atanas G. Atanasov, Piotr Religa and Michel Edwar Mickael
Curr. Issues Mol. Biol. 2025, 47(5), 381; https://doi.org/10.3390/cimb47050381 - 21 May 2025
Viewed by 1364
Abstract
Acute lymphoblastic leukemia (ALL) accounts for approximately 25% of childhood cancers and 20% of leukemia cases in adults, with a higher prevalence in males than females. It is characterized by symptoms such as fatigue, fever, and bone pain and poses a significant risk [...] Read more.
Acute lymphoblastic leukemia (ALL) accounts for approximately 25% of childhood cancers and 20% of leukemia cases in adults, with a higher prevalence in males than females. It is characterized by symptoms such as fatigue, fever, and bone pain and poses a significant risk of mortality if left untreated. While chemotherapy and stem cell transplantation are standard treatments, their efficacy declines in relapsed or refractory cases, highlighting the need for innovative therapeutic approaches. CAR T-cell therapy has emerged as a transformative technology, offering the potential to overcome these challenges and deliver durable remissions. CAR T-cell therapy demonstrates significant advantages, including targeting specific antigens, overcoming high-risk genetic mutations, and achieving sustained remissions in both pediatric and adult patients. However, notable challenges remain, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). In this review, we focus on neurological symptoms associated with CAR T-cell therapy in treating ALL and discuss current and future strategies aiming at reducing their risk. Full article
(This article belongs to the Special Issue Novel Immunotherapy for Neurological Diseases)
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