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Special Issue Editor

Dr. Ana Isabel Burguete-Garcia

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Guest Editor

Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico
Interests: gut microbiota; chronic diseases; genetic epidemiology; infectious diseases

Special Issue Information

Dear Colleagues,

This Special Issue encompasses studies of the human gut microbiota and its impact on children's health and disease. Studies on the development of non-communicable diseases, central obesity/obesity, neurodevelopment, and gastrointestinal, immunological, inflammatory, and metabolic disorders; on the interaction of diet and the environment; novel studies using applied technologies; and on the biological–causal mechanism of the effect of the intestinal microbiota on health and disease in children will be considered for publication.

Dr. Ana Isabel Burguete-Garcia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

gut microbiota
children health
obesity
metabolic disorders
diet
noncommunicable diseases
neurodevelopment
immune response

Published Papers (2 papers)

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Research

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22 pages, 3329 KiB

Open AccessArticle

Effects of Physical Activity and Nutrition Education on the Gut Microbiota in Overweight and Obese Children

by Micaela C. Morgado, Mónica Sousa, Cláudia Marques, André B. Coelho, Júlio A. Costa and André Seabra

Children 2023, 10(7), 1242; https://doi.org/10.3390/children10071242 - 19 Jul 2023

Cited by 1 | Viewed by 1685

Abstract

Childhood obesity continues to represent a growing challenge, and it has been associated with gut microbiota dysbiosis. This study examines the gut microbiota composition in overweight and obese school children and assesses whether a 12-week multidisciplinary intervention can induce changes in the gut microbiota. The intervention, which combined recreational football and nutritional education, was implemented among 15 school children, aged 7–10 years, with a Body Mass Index ≥ 85th percentile. The children were assigned into two groups: Football Group (n = 9) and Nutrition and Football Group (n = 6). Faecal samples were collected at the beginning and end of the program and analysed by sequencing the 16S rRNA gene. Over the intervention, a significant decrease was found collectively for Bifidobacterium genera (p = 0.011) and for Roseburia genera in the Football Group (p = 0.021). The relative abundance of Roseburia (p = 0.002) and Roseburia faecis (p = 0.009) was negatively correlated with moderate to vigorous physical activity (MVPA), while Prevotella copri was positively correlated with MVPA (p = 0.010) and with the daily intake of protein (p = 0.008). Our findings suggest that a multidisciplinary intervention was capable of inducing limited but significant positive changes in the gut microbiota composition in overweight and obese school children. Full article

(This article belongs to the Special Issue Gut Microbiota and Metabolic Health in Children)

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Other

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14 pages, 621 KiB

Open AccessSystematic Review

The Role of the Gut Microbiome in Youth with Polycystic Ovary Syndrome: A Systematic Review

by Vasiliki-Rengina Tsinopoulou, Eleni P. Kotanidou, Nikolaos Athanasiadis, Evdoxia Sapountzi, Flora Bacopoulou, Evangelia Ntzani, Assimina Galli-Tsinopoulou and Athanasios Christoforidis

Children 2023, 10(12), 1872; https://doi.org/10.3390/children10121872 - 29 Nov 2023

Viewed by 987

Abstract

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and female adolescents. The diagnosis of PCOS is difficult during puberty due to overlapping of the criteria with normal variations of menstruation during this age period. There are insufficient data on the gut microbiome and PCOS and potential mechanisms linking the two. The present systematic review aimed to detect dysbiosis patterns in youth with PCOS, compared with healthy controls. Methods: One hundred seventy-eight studies were identified by a databases search and sixty-eight by a full-text assessment for eligibility; four were included in the systematic review and underwent quality control. Results: The results of the study were controversial in accordance to findings from the literature. A change in gut microbiome α diversity was found in PCOS adolescents, with no significant alterations in β diversity. Almost all studies found Firmicutes, Bacteroidetes, and Actinobacteria in abundance in both groups, with changes in family composition and fluctuations at the phylum level. A statistically significant association between these changes and clinical or biochemical features of the syndrome was described. Conclusions: This systematic review confirmed gut microbiota dysbiosis in youth with PCOS. However, further data are needed to clarify these changes and to build a strategy to prevent the syndrome. Full article

(This article belongs to the Special Issue Gut Microbiota and Metabolic Health in Children)

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