Evaluation and Management of Children with Congenital Heart Disease

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Cardiology".

Deadline for manuscript submissions: 1 December 2025 | Viewed by 331

Special Issue Editors


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Guest Editor
Department of Experimental and Clinical Medicine, Magna Grecia University, 88100 Catanzaro, Italy
Interests: cardiovascular imaging; echocardiography; cardiac magnetic resonance

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Guest Editor
Paediatric Cardiology Unit, Department of Woman’s and Child’s Health, University-Hospital of Padova, University of Padua, Padua, Italy
Interests: congenital heart disease; cardiovascular imaging; echocardiography

Special Issue Information

Dear Colleagues,

Congenital heart disease (CHD) has seen remarkable advancements over recent decades, revolutionizing care and greatly improving outcomes for millions of individuals born with this condition. Despite these strides, CHD remains a chronic, lifelong condition that continues to pose significant challenges, with many patients experiencing ongoing health complications and increased risk of mortality. To further advance outcomes, global efforts must focus on improving clinical management, refining diagnostic and prognostic tools, and developing strategies for modifying disease progression. These efforts will eventually result in improved patient outcomes and quality of life, with a substantial benefit to healthcare systems. The aim of this Special Issue is to collect contributions spanning the full spectrum of CHD, from initial evaluation through diagnostic and therapeutic pathways to address the evolving needs of this unique patient population.

Dr. Isabella Leo
Dr. Martina Avesani
Guest Editors

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Keywords

  • congenital heart disease (CHD)
  • pediatric cardiology
  • cardiovascular imaging
  • cardiomyopathy
  • atrial septal defect
  • tetralogy of fallot
  • echocardiography
  • cardiovascular magnetic resonance

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Published Papers (1 paper)

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Review

21 pages, 1699 KiB  
Review
Cardiac Hypertrophy: A Comprehensive Review from Prenatal Life to Young Adulthood
by Martina Avesani, Elettra Pomiato, Sara Moscatelli, Jolanda Sabatino, Nunzia Borrelli, Leonie Luedke, Rosalba De Sarro, Sara Pavesi, Giulia Pelaia, Claudio Mastellone, Isabella Leo and Giovanni Di Salvo
Children 2025, 12(8), 989; https://doi.org/10.3390/children12080989 - 28 Jul 2025
Abstract
Myocardial hypertrophy (MH) represents a complex and heterogeneous condition in the pediatric and young adult population. While rare in children, MH encompasses a wide spectrum of physiological and pathological entities, ranging from transient hypertrophy in the infants of diabetic mothers to progressive genetic [...] Read more.
Myocardial hypertrophy (MH) represents a complex and heterogeneous condition in the pediatric and young adult population. While rare in children, MH encompasses a wide spectrum of physiological and pathological entities, ranging from transient hypertrophy in the infants of diabetic mothers to progressive genetic hypertrophic cardiomyopathies (HCM) with significant morbidity and mortality. Differential diagnosis is critical, as many phenocopies—including metabolic, mitochondrial, and syndromic diseases—can mimic HCM. Echocardiography remains the first-line imaging modality, with cardiac magnetic resonance (CMR) and molecular diagnostics increasingly used for detailed characterization. Risk stratification tools, such as the HCM Risk-Kids model, support clinical decision-making but must be integrated with individualized assessment. Advances in prenatal screening and genetic testing have significantly improved outcomes, though long-term management requires multidisciplinary care. Understanding age-specific presentations and the underlying etiologies is essential for accurate diagnosis and targeted treatment. This review provides a comprehensive overview of cardiac hypertrophy from fetal life through young adulthood, with a focus on etiologies, diagnostic approaches, imaging modalities, and therapeutic strategies, and aims to guide clinicians through the evolving landscape of MH, emphasizing early recognition, comprehensive evaluation, and personalized care. Full article
(This article belongs to the Special Issue Evaluation and Management of Children with Congenital Heart Disease)
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