Neonatal and Pediatric Sepsis: Focus on Pathogenesis and Treatment Strategies
A Special Issue of Children (ISSN 2227-9067) belonging to the section "Pediatric Infectious Diseases".
Deadline for manuscript submissions: 5 November 2026 | Viewed by 240
Editors
2. “Filantropia” Clinical Municipal Hospital, 200143 Craiova, Romania
Interests: prematurity; anemia; neonatology; sepsis; neonatal intensive care
Interests: maternal fetal medicine; cervical pathology; first trimester ultrasound scan; anomaly scan; intrapartum ultrasound
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neonatal and pediatric sepsis represents a major cause of neonatal and pediatric morbidity and mortality despite advanced technology for diagnosis and treatment. Sepsis is the most challenging condition to diagnose early for neonates. Globally, neonatal infections account for 11–19% of all neonatal deaths, with an unequal distribution according to healthcare system resources. The pathogenic mechanisms of EOS include pathogen-induced inflammation, systemic inflammation, sterile inflammation, and interactions between mechanistic pathways; emerging molecular biomarker detection needs to be completed with clinical signs to improve the existing criteria. Further research is needed to improve the systemic inflammatory response syndrome (SIRS) criteria that is applicable to neonates, such as fetal inflammatory response syndrome (FlRS). Even Sequential Organ Failure Assessment (SOFA) scores, which associate clinical components, are poor predictors of sepsis.
The aim of this Special Issue is to discover new biomarkers and clinical patterns for the early diagnosis and treatment of sepsis, and to find new balanced and cost-effective pathways for management of neonatal sepsis. To prevent sepsis, antimicrobial stewardship programs should be developed, starting in the NICU, to minimize short-term and long-term side-effects. This Special Issue also aims to highlight the importance of preventive strategies for sepsis.
This Special Issue invites research in the form of articles or systematic reviews; each research result can make a big difference in managing neonatal or pediatric sepsis.
Dr. Mirela Anişoara Siminel
Dr. Dominic Gabriel Iliescu
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sepsis
- EOS neonatal sepsis
- LOS neonatal sepsis
- pediatric infectious diseases
- sepsis treatment
- sepsis biomarker
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