Advances in Prenatal Diagnosis and Their Impact on Neonatal Outcomes

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: 30 September 2025 | Viewed by 650

Special Issue Editors


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Guest Editor
1. Department of Materno-Fetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocio/CSIC/University of Seville, 41013 Seville, Spain
2. Fetal, IVF and Reproduction Simulation Training Center (FIRST), 41010 Seville, Spain
3. Centre for Biomedical Network Research on Rare Diseases (CIBERER), 41013 Seville, Spain
Interests: fetal medicine; fetal therapy; prenatal diagnosis; prenatal genetics; genomics

E-Mail Website
Guest Editor
1. Department of Materno-Fetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocio/CSIC/University of Seville, 41013 Seville, Spain
2. Department of Surgery, University of Seville, 41013 Seville, Spain
Interests: fetal medicine; fetal therapy; prenatal diagnosis; prenatal genetics; genomics

Special Issue Information

Dear Colleagues,

Prenatal diagnosis has revolutionized perinatal care, enabling the early detection of fetal conditions and guiding interventions that profoundly influence neonatal outcomes. Since its inception with the advent of ultrasound and genetic testing, this field has evolved into a multidisciplinary domain integrating advanced imaging, molecular diagnostics, and computational technologies. These advances have not only improved diagnostic accuracy but have also expanded our understanding of the fetal environment and its long-term implications.

This Special Issue aims to explore the latest developments in prenatal diagnosis and their direct and indirect impacts on neonatal health. We seek to highlight cutting-edge research that bridges the gap between prenatal findings and neonatal care, addressing both clinical and technological innovations.
We welcome submissions focusing on novel diagnostic techniques, predictive models for neonatal outcomes, interventional approaches, and ethical considerations in prenatal care. Original research articles, reviews, and case studies that showcase interdisciplinary collaboration are particularly encouraged, fostering a comprehensive understanding of this critical continuum in medicine.

Dr. Ángel Chimenea-Toscano
Dr. Lutgardo García-Díaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prenatal diagnosis
  • neonatal outcomes
  • fetal medicine
  • perinatal care
  • predictive models
  • advanced imaging
  • interventional approaches

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Published Papers (1 paper)

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Research

12 pages, 2927 KiB  
Article
Predictive Value of Maternal HbA1c Levels for Fetal Hypertrophic Cardiomyopathy in Pregestational Diabetic Pregnancies
by Angel Chimenea, Ana María Calderón, Guillermo Antiñolo, Eduardo Moreno-Reina and Lutgardo García-Díaz
Children 2025, 12(3), 312; https://doi.org/10.3390/children12030312 - 28 Feb 2025
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Abstract
(1) Background: This study investigated the utility of first-visit HbA1c levels as a predictor of fetal hypertrophic cardiomyopathy (FHCM) in women with pregestational diabetes mellitus (PGDM). (2) Methods: A retrospective observational cohort study was conducted among all pregnant women with PGDM between 2012 [...] Read more.
(1) Background: This study investigated the utility of first-visit HbA1c levels as a predictor of fetal hypertrophic cardiomyopathy (FHCM) in women with pregestational diabetes mellitus (PGDM). (2) Methods: A retrospective observational cohort study was conducted among all pregnant women with PGDM between 2012 and 2019. (3) Results: Of 329 participants, 5.8% had fetuses diagnosed with FHCM. These women exhibited significantly higher pregestational HbA1c (8.2% vs. 7.3%, p = 0.003) and higher first-visit HbA1c (7.6% vs. 6.9%, p = 0.001) and were less likely to have planned their pregnancies (p = 0.035). Fetuses with FHCM demonstrated a higher incidence of macrosomia (63.2% vs. 17.7%, p < 0.001; OR 9.20, 95% CI 3.31–25.58). Receiver-operating characteristic (ROC) analysis indicated an adequate predictive capacity for FHCM using first-visit HbA1c (AUC 0.75). An HbA1c threshold of 7.15% provided the best discriminative power, encompassing 38.9% of the cohort. (4) Conclusions: These findings underscore the value of assessing first-visit HbA1c levels for predicting FHCM in women with PGDM. The significant association between glycemic status and FHCM highlights the importance of optimizing glycemic control before and during pregnancy. Establishing optimal HbA1c cutoffs enables effective risk stratification and supports targeted clinical interventions. Full article
(This article belongs to the Special Issue Advances in Prenatal Diagnosis and Their Impact on Neonatal Outcomes)
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