Electrochemical Sensors for Food Control, Environmental Analysis, and Diagnosis in Medicine

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Electrochemical Devices and Sensors".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 17223

Special Issue Editors


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Guest Editor
International Centre of Biodynamics, 1B Intrarea Portocalelor, 060101 Bucharest, Romania
Interests: analytical chemistry; biosensors; electrochemical sensors; aptamers; wine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Medicine, Research Centre for Fundamental Research and Prevention Strategies in Medicine, Transilvania University of Brasov, B-dul Eroilor nr 29, 500036 Brasov, Romania
Interests: bioanalytical methods; electrochemical (bio) sensors; biochemistry; antioxidants detection; telemedicine; plant food supplements
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Universite de Perpignan Via Domitia, 52 Avenue Paul Alduy, CEDEX, 66860 Perpignan, France
Interests: electrochemical and optical biosensors; aptasensors for food and environmental control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Electrochemical sensors, as important analytical devices, are widely used for the determination of a broad range of analytes in several fields, including food control, environmental monitoring, and diagnostic analysis, due to their unique properties, such as functional diversity, miniaturization, intelligence, low cost, immediate application, and high sensitivity.

This Special Issue aims to cover various aspects of electrochemical sensors and their applications. We invite all researchers working on electrochemical sensors to submit their original research studies to this Special Issue. Both review articles and research papers are welcome.

The areas of particular interest to this Special Issue include but are not limited to:

  • Electrochemical sensors and biosensors
  • Screen-printed electrodes
  • Electrochemical analysis
  • DNA sensors
  • Immunosensor
  • Biosensor, biochip
  • Nanomaterials

Papers presented in the frame of the international conference “New Trends on Sensing-Monitoring-Telediagnosis for Life Sciences”— NT SMT-LS 2022 (http://www.healthfoodenviron.unitbv.ro/2022/), September 8–10, 2022, Brasov, Romania, will receive a special discount of at least 50% if the article is accepted by at least two independent reviewers of the journal. Authors whose papers were selected for the conference will be invited to submit extended versions of their original papers and contributions (a 50% extension of the contents of the conference paper is required). 

Dr. Alina Vasilescu
Prof. Dr. Mihaela Badea
Prof. Dr. Jean Louis Marty
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (7 papers)

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Research

Jump to: Review

14 pages, 2455 KiB  
Article
Two-Dimensional Tellurium Nanosheets for the Efficient Nonenzymatic Electrochemical Detection of H2O2
by Amit Kumar Shringi, Rajeev Kumar, Netanya F. Dennis and Fei Yan
Chemosensors 2024, 12(2), 17; https://doi.org/10.3390/chemosensors12020017 - 23 Jan 2024
Viewed by 1568
Abstract
This study reports, for the first time, the utilization of two-dimensional (2D) tellurium (Te) nanosheets for the efficient nonenzymatic detection of hydrogen peroxide (H2O2). H2O2 acts as a pivotal biomarker with widespread applications across environmental, biological, [...] Read more.
This study reports, for the first time, the utilization of two-dimensional (2D) tellurium (Te) nanosheets for the efficient nonenzymatic detection of hydrogen peroxide (H2O2). H2O2 acts as a pivotal biomarker with widespread applications across environmental, biological, industrial, and food processing domains. However, an excessive accumulation of H2O2 in the body poses a severe threat to human life. Consequently, the imperative need for a selective, sensitive, and cost-effective sensing platform for H2O2 detection has gained paramount significance. Employing a low-cost and straightforward hydrothermal method, Te nanosheets were synthesized to address the escalating demand for a reliable detection platform. The as-synthesized Te nanosheets are characterized through Raman spectroscopy and atomic force microscopy techniques. The electrochemical performance of the Te nanosheets integrated onto a glassy carbon (Te-GC) electrode was thoroughly investigated using cyclic voltammetry, differential pulse voltammetry, and chronoamperometry. The experiments were designed to evaluate the response of the Te-GC electrode in the presence and absence of H2O2, alongside its performance in the detection of other pertinent interfering analytes. The sensor shows a limit of detection of 0.47 µM and a sensitivity of 27.2 µA µM−1 cm−2 towards H2O2. The outcomes of this study demonstrate the efficacy of Te nanosheets as a promising material for nonenzymatic H2O2 detection in urine samples. The simplicity and cost-effectiveness of the hydrothermal synthesis process, coupled with the notable electrochemical performance of the Te/GC electrode, highlight the potential of Te nanosheets in the development of a robust sensing platform. This research contributes to the ongoing efforts to enhance our capabilities in monitoring and detecting H2O2, fostering advancements in environmental, biomedical, and industrial applications. Full article
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16 pages, 20001 KiB  
Article
Simulation of Electrical Biofilm Impedance to Determine the Sensitivity of Electrode Geometries
by Chris Gansauge, Danny Echtermeyer and Dieter Frense
Chemosensors 2024, 12(1), 14; https://doi.org/10.3390/chemosensors12010014 - 16 Jan 2024
Viewed by 1412
Abstract
Biofilms are ubiquitous at interfaces of natural and technical origin. Depending on type and application, biofilm formation is desired or has to be prevented. Therefore, reliable detection of initial biofilm growth is essential in many areas. One method of biofilm monitoring is the [...] Read more.
Biofilms are ubiquitous at interfaces of natural and technical origin. Depending on type and application, biofilm formation is desired or has to be prevented. Therefore, reliable detection of initial biofilm growth is essential in many areas. One method of biofilm monitoring is the electrochemical impedance spectroscopy. Among other factors, this method is heavily dependent on the electrode geometry. In order to achieve a high measurement sensitivity, the electrode size must be chosen according to the biofilm that is to be measured. This paper presents an approach for simulating and modeling the optimal electrode geometry for a specific biofilm. First, a geometric model of a biofilm with up to 6000 individual bacteria is generated. The simulated impedances are used to calculate which electrode geometry maximizes sensitivity depending on the biofilm height. In the chosen example of an E. coli biofilm in a nutrient solution, the optimum size of an interdigital electrode (bar gap equals width) was 2.5 µm for a biofilm height of up to 2 µm. The used algorithms and models can be simply adapted for other biofilms. In this way, the most sensitive electrode geometry for a specific biofilm measurement can be determined with minimal effort. Full article
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11 pages, 2401 KiB  
Article
Fabrication of Large-Area Ordered Au Nano-Ring Arrays for the Electrochemical Removal and Sensing of Rhodamine 6G Molecules
by Xun Cao
Chemosensors 2023, 11(10), 539; https://doi.org/10.3390/chemosensors11100539 - 13 Oct 2023
Viewed by 1337
Abstract
To understand the formation process of ordered Au nano-ring arrays (NRA), a series of factors—including etchant gas and flow rate, chamber pressure and RF power—were systematically studied and a set of optimum parameters were deduced to fabricate this interesting structure. With plenty of [...] Read more.
To understand the formation process of ordered Au nano-ring arrays (NRA), a series of factors—including etchant gas and flow rate, chamber pressure and RF power—were systematically studied and a set of optimum parameters were deduced to fabricate this interesting structure. With plenty of active sites previously reported, a new role of ordered Au NRA is unlocked in this work. The ordered Au NRA could perform the electrochemical removal of rhodamine 6G (R-6G) at a high concentration in seawater within 12 min and complete discoloration within 9 min, which demonstrates ~7 times efficiency improvement from previous studies. The nanostructured surface also makes the ordered Au NRA a good substrate material in R-6G sensing using surface-enhanced Raman spectroscopy, which performs with better accuracy than the ultraviolet–visible light technique. Full article
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17 pages, 3444 KiB  
Article
Anodic Stripping Voltammetric Determination of Copper Ions in Cell Culture Media: From Transwell® to Organ-on-Chip Systems
by Carmela Tania Prontera, Elisa Sciurti, Chiara De Pascali, Lucia Giampetruzzi, Francesco Biscaglia, Laura Blasi, Vanessa Esposito, Flavio Casino, Pietro Aleardo Siciliano and Luca Nunzio Francioso
Chemosensors 2023, 11(8), 466; https://doi.org/10.3390/chemosensors11080466 - 21 Aug 2023
Cited by 2 | Viewed by 1128
Abstract
The integration of sensing devices into cell culture systems is a topic of great interest in the study of pathologies and complex biological mechanisms in real-time. In particular, the fit-for-purpose microfluidic devices called organ-on-chip (OoC), which host living engineered organs that mimic in [...] Read more.
The integration of sensing devices into cell culture systems is a topic of great interest in the study of pathologies and complex biological mechanisms in real-time. In particular, the fit-for-purpose microfluidic devices called organ-on-chip (OoC), which host living engineered organs that mimic in vivo conditions, benefit greatly from the integration of sensors, enabling the monitoring of specific chemical-physical parameters that can be correlated with biological processes. In this context, copper is an essential trace element whose total concentration may be associated with specific pathologies, and it is therefore important to develop reliable analytical techniques in cell systems. Copper can be determined by using the anodic stripping voltammetry (ASV) technique, but its applicability in cell culture media presents several challenges. Therefore, in this work, the performance of ASV in cell culture media was evaluated, and an acidification protocol was tested to improve the voltammetric signal intensity. A Transwell® culture model with Caco-2 cells was used to test the applicability of the developed acidification protocol by performing an off-line measurement. Finally, a microfluidic device was designed in order to perform the acidification of the cell culture medium in an automated manner and then integrated with a silicon microelectrode to perform in situ measurements. The resulting sensor-integrated microfluidic chip could be used to monitor the concentration of copper or other ions concentration in an organ-on-chip model; these functionalities represent a great opportunity for the non-destructive strategic experiments required on biological systems under conditions close to those in vivo. Full article
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16 pages, 3361 KiB  
Article
Design, Elaboration, and Characterization of an Immunosensor for the Detection of a Fungal Toxin in Foodstuff Analyses
by Zeineb Ben Abdallah, Halim Sghaier, Ibtissem Gammoudi, Fabien Moroté, Sébastien Cassagnère, Lena Romo, Laure Béven, Christine Grauby-Heywang and Touria Cohen-Bouhacina
Chemosensors 2022, 10(4), 137; https://doi.org/10.3390/chemosensors10040137 - 06 Apr 2022
Cited by 3 | Viewed by 2003
Abstract
This work describes the complete elaboration of an immunosensor for the detection of the fungal B1 aflatoxin (AFB1). In a first step, a system made of three screen-printed electrodes (SPEs) was manufactured using gold, silver/silver chloride, and carbon pastes. Raman spectroscopy showed that [...] Read more.
This work describes the complete elaboration of an immunosensor for the detection of the fungal B1 aflatoxin (AFB1). In a first step, a system made of three screen-printed electrodes (SPEs) was manufactured using gold, silver/silver chloride, and carbon pastes. Raman spectroscopy showed that the thermal treatment applied to the electrodes enabled a strong decrease in the amount of undesirable organic molecules for each paste. Atomic Force Microscopy was also used to reveal the morphology of the electrode surfaces. In a second step, an autonomous and cheap electronic system was designed for the control of the sensor and electrochemical measurements, showing current variations significantly higher than those observed with a commercial system. In a last step, the gold working electrode of this system was functionalized by a simple self-assembly method, optimized in a previous work, with a molecular architecture including an antibody recognizing specifically AFB1. The complete device was finally realized by combining the SPEs and the electronic platform. The resulting setup was able to detect AFB1 toxin in a buffer with an LOD of about 50 fg/mL. It was then applied to the detection of AFB1 in rice milk, a more realistic medium comparable with those met in an agrifood context. The electrochemical detection of AFB1 was possible in a range of concentration between 0.5 pg/mL and 2.5 pg/mL, with the sensor behaving linearly in this range. Full article
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Review

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20 pages, 1476 KiB  
Review
New Trends in Uric Acid Electroanalysis
by Ligia Chelmea, Mihaela Badea, Ioan Scarneciu, Marius Alexandru Moga, Lorena Dima, Patrizia Restani, Cecilia Murdaca, Daniel Ciurescu and Laura Elena Gaman
Chemosensors 2023, 11(6), 341; https://doi.org/10.3390/chemosensors11060341 - 09 Jun 2023
Cited by 1 | Viewed by 1614
Abstract
Considering the increasing incidence of hyperuricemia and oxidative stress-related diseases, quantification of uric acid has become essential. Therefore, the evolution on sensing devices being favorable, these questions are more often addressed to the field of medical researchers. As for many metabolites, (bio)sensors provide [...] Read more.
Considering the increasing incidence of hyperuricemia and oxidative stress-related diseases, quantification of uric acid has become essential. Therefore, the evolution on sensing devices being favorable, these questions are more often addressed to the field of medical researchers. As for many metabolites, (bio)sensors provide a reliable method for screening and evaluation of uric acid status. Due to the numerous categories of (bio)sensors available, choosing the appropriate one is a challenge. This study reviews the scientific information concerning the most suitable (bio)sensors for quantification of uric acid, presenting a list of sensors from the last decade, categorized by configurations and materials. In addition, this review includes a comparison of sensors according to their interference behavior and sensitivity, offering an objective perspective for identifying devices that are suitable for clinical applications. Full article
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26 pages, 2255 KiB  
Review
Electrochemical Sensing for Vitamins
by Yanting Yang, Ning Hu, Jinan Deng and Jun Yang
Chemosensors 2022, 10(11), 494; https://doi.org/10.3390/chemosensors10110494 - 21 Nov 2022
Cited by 5 | Viewed by 6432
Abstract
Vitamins are essential and necessary nutrients for the human body. Rapid and accurate quantification of their levels in various samples has attracted much attention. Compared with traditional analytical methods, electrochemical techniques, with the advantages of low cost, high sensitivity, flexible detection strategies, easy [...] Read more.
Vitamins are essential and necessary nutrients for the human body. Rapid and accurate quantification of their levels in various samples has attracted much attention. Compared with traditional analytical methods, electrochemical techniques, with the advantages of low cost, high sensitivity, flexible detection strategies, easy integration, and miniaturization, have gradually become the main tools in vitamin detection. In this paper, the advance of electrochemical sensing of vitamins in recent years is reviewed. Firstly, the basics of different vitamins are briefly introduced. Then, the commonly-used electrodes and electrochemical methods for vitamin electrochemical detection, as well as the specific implementation strategy and performance, are described in detail. The development of miniaturization devices, especially microfluidic and microsensor devices, is also presented. Finally, the challenges faced by the electrochemical detection of vitamins are discussed, and future development is prospected. Full article
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