Recent Advances in Liver Repair Strategies
A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Cellular Pathology".
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Interests: liver cell therapy; mesenchymal stem cells; liver regeneration; hepatogenic differentiation; liver defects; cell therapy; liver cell types
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Topical Collection Information
Dear Colleagues,
The liver is a masterful organ that orchestrates the coordination of over 500 functions essential for life. Compared with other organs, the liver displays a high ability to regenerate itself—a well-conserved feature from fish to humans—which is crucial to preserve the coordination of those critical functions. Because such a complex and critical organ may experience several problems, keeping the liver healthy is a necessity to maintain its regeneration potential. Once this ability is altered, significant structural and functional changes occur that could alter other organs.
Liver diseases—either inherited or acquired—are continuously increasing, and represent a significant cause of mortality worldwide. Orthotopic liver transplantation (OLT) remains the gold standard therapeutic option. Unfortunately, it is not widely accessible to all patients for several reasons, among which is the significantly increased donor scarcity. Accordingly, investigations are continuously conducted to develop novel and innovative therapeutic strategies that could support and/or substitute OLT. This could be achieved via the improvement and strengthening of our knowledge on liver diseases, as well as on the underlined cellular and molecular mechanisms hampering the liver regeneration potential.
This Topical Collection will address all aspects related to liver biology, liver diseases, and early proof of concept investigations that are developing novel clinical solutions. It welcomes high-quality basic and clinical research papers as well as reviews that emphasize these issues.
Dr. Mustapha Najimi
Guest Editor
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Keywords
- liver
- liver diseases
- signaling pathway
- cell therapy
- tissue engineering
- gene therapy
- transplantation
- stem cells
- tissue regeneration