Protein Tyrosine Phosphatases (PTPs) in Development and Human Diseases

Dear Colleagues,

The regulation of protein tyrosine phosphorylation by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) plays a pivotal role in a wide range of biological processes such as membrane trafficking, redox signaling, cell growth, differentiation, cell migration, and apoptosis. While many aspects of tyrosine phosphorylation-mediated signaling have been discovered from studies of PTKs, recent data have indicated the importance of PTPs in coordinating these signaling pathways. Unlike serine/threonine phosphatases, PTPs constitute a large and structurally diverse family of enzymes. Dysregulation of PTPs has been associated with a variety of diseases such as cancer, neurodegeneration, metabolic and cardiovascular disorders, and autoimmune diseases. Recent advances in structural and mass spectrometry analysis have revealed the dynamic conformation of PTPs and may provide important information for targeted drug design.

This Special Issue focuses on protein tyrosine phosphorylation in normal development and diseases, with an emphasis on PTP-mediated signaling and novel therapeutic indications of these enzymes. Both original research articles and reviews are welcome.

Dr. Tzu-Ching Meng
Dr. Guang-Chao Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Tyrosine kinases
• Tyrosine phosphatases
• Signal transduction
• Membrane trafficking
• Redox and stress signaling
• Human diseases
• Development