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Cells
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Platelet Function and Platelet Proteomics in Ageing-Related Diseases
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Platelet Function and Platelet Proteomics in Ageing-Related Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 4175

Special Issue Editor

Dr. Maria Zellner

E-Mail Website
Guest Editor
Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Interests: platelet biology; thrombosis; vasular biology

Special Issue Information

Dear Colleagues,

Aging is the predominant risk factor for VTE, pulmonary embolism, stroke and coronary artery disease (CAD). Since platelets are critically responsible for the lethal consequences of thrombosis, it is assumed that blood platelets play a central role in age-related diseases. In addition, emerging data show that platelets also possess various properties that reflect pathophysiological signs of age-related neurological disorders such as Alzheimer's disease.

Aging is associated with energy deficit and increased production of reactive oxygen species (ROS). Mitochondria are known to be strong producers of ROS. These ROS damage lipids, proteins, and especially mitochondrial DNA. Due to the latter, however, mitochondria are also very susceptible to oxidative damage. In blood circulation, platelets have the major reservoir of mitochondria, and platelet mitochondria have been implicated in platelet activation and thereby thrombosis

Platelets are very sensitive to oxidative stress since hydrogen peroxides are involved in signal transduction of platelet activation. Platelets of elderly display increased generation of reactive oxygen species and an enhanced responsiveness to aggregating stimuli. This age-related platelet hyperreactivity leads to increased interactions with neutrophils and monocytes, which leads to injurious thromboinflammatory events.

The aim of this Special Issue is to provide an overview of the current knowledge of molecular mechanisms regarding changes in platelets of age-related diseases Studies that uncover functional connections are likely to identify new mechanisms that lead to age-related changes in platelet proteome and function. Research into the mechanisms that cause age-related changes in platelets will help to reduce oxidative stress, thromboinflammation, and the risk of thrombosis in older adults.

The current Special Issue will accept original studies, reviews and technical reports in the field of platelet studies in age-related diseases, written by scientists active in the field.

Dr. Maria Zellner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • thrombosis
  • platelets
  • platelet reactivity
  • platelet function
  • proteomics
  • age-related diseases
  • oxidative stress
  • mitochondria
  • microvesicles
  • thromboinflammation
  • hemostasis

Published Papers (2 papers)

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Research

14 pages, 3881 KiB  
Article
Age-Dependent Surface Receptor Expression Patterns in Immature Versus Mature Platelets in Mouse Models of Regenerative Thrombocytopenia
by Anita Pirabe, Sabine Frühwirth, Laura Brunnthaler, Hubert Hackl, Anna Schmuckenschlager, Waltraud C. Schrottmaier and Alice Assinger
Cells 2023, 12(19), 2419; https://doi.org/10.3390/cells12192419 - 8 Oct 2023
Viewed by 1206
Abstract
Aging is a multifaceted process that unfolds at both the individual and cellular levels, resulting in changes in platelet count and platelet reactivity. These alterations are influenced by shifts in platelet production, as well as by various environmental factors that affect circulating platelets. [...] Read more.
Aging is a multifaceted process that unfolds at both the individual and cellular levels, resulting in changes in platelet count and platelet reactivity. These alterations are influenced by shifts in platelet production, as well as by various environmental factors that affect circulating platelets. Aging also triggers functional changes in platelets, including a reduction in RNA content and protein production capacity. Older individuals and RNA-rich immature platelets often exhibit hyperactivity, contributing significantly to pathologic conditions such as cardiovascular diseases, sepsis, and thrombosis. However, the impact of aging on surface receptor expression of circulating platelets, particularly whether these effects vary between immature and mature platelets, remains largely unexplored. Thus, we investigated the expression of certain surface and activation receptors on platelets from young and old mice as well as on immature and mature platelets from mouse models of regenerative thrombocytopenia by flow cytometry. Our findings indicate that aged mice show an upregulated expression of the platelet endothelial cell adhesion molecule-1 (CD31), tetraspanin-29 (CD9), and Toll-like receptor 2 (TLR2) compared to their younger counterparts. Interestingly, when comparing immature and mature platelets in both young and old mice, no differences were observed in mature platelets. However, immature platelets from young mice displayed higher surface expression compared to immature platelets from old mice. Additionally, in mouse models of regenerative thrombocytopenia, the majority of receptors were upregulated in immature platelets. These results suggest that distinct surface receptor expressions are increased on platelets from old mice and immature platelets, which may partially explain their heightened activity and contribute to an increased thrombotic risk. Full article
(This article belongs to the Special Issue Platelet Function and Platelet Proteomics in Ageing-Related Diseases)
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15 pages, 3290 KiB  
Article
A Multi-Trait Association Analysis of Brain Disorders and Platelet Traits Identifies Novel Susceptibility Loci for Major Depression, Alzheimer’s and Parkinson’s Disease
by Alfonsina Tirozzi, Miriam Shasa Quiccione, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello and Alessandro Gialluisi
Cells 2023, 12(2), 245; https://doi.org/10.3390/cells12020245 - 6 Jan 2023
Cited by 2 | Viewed by 2326
Abstract
Among candidate neurodegenerative/neuropsychiatric risk-predictive biomarkers, platelet count, mean platelet volume and platelet distribution width have been associated with the risk of major depressive disorder (MDD), Alzheimer’s disease (AD) and Parkinson’s disease (PD) through epidemiological and genomic studies, suggesting partial co-heritability. We exploited these [...] Read more.
Among candidate neurodegenerative/neuropsychiatric risk-predictive biomarkers, platelet count, mean platelet volume and platelet distribution width have been associated with the risk of major depressive disorder (MDD), Alzheimer’s disease (AD) and Parkinson’s disease (PD) through epidemiological and genomic studies, suggesting partial co-heritability. We exploited these relationships for a multi-trait association analysis, using publicly available summary statistics of genome-wide association studies (GWASs) of all traits reported above. Gene-based enrichment tests were carried out, as well as a network analysis of significantly enriched genes. We analyzed 4,540,326 single nucleotide polymorphisms shared among the analyzed GWASs, observing 149 genome-wide significant multi-trait LD-independent associations (p < 5 × 10−8) for AD, 70 for PD and 139 for MDD. Among these, 27 novel associations were detected for AD, 34 for PD and 40 for MDD. Out of 18,781 genes with annotated variants within ±10 kb, 62 genes were enriched for associations with AD, 70 with PD and 125 with MDD (p < 2.7 × 10−6). Of these, seven genes were novel susceptibility loci for AD (EPPK1, TTLL1, PACSIN2, TPM4, PIF1, ZNF689, AZGP1P1), two for PD (SLC26A1, EFNA3) and two for MDD (HSPH1, TRMT61A). The resulting network showed a significant excess of interactions (enrichment p = 1.0 × 10−16). The novel genes that were identified are involved in the organization of cytoskeletal architecture (EPPK1, TTLL1, PACSIN2, TPM4), telomere shortening (PIF1), the regulation of cellular aging (ZNF689, AZGP1P1) and neurodevelopment (EFNA3), thus, providing novel insights into the shared underlying biology of brain disorders and platelet parameters. Full article
(This article belongs to the Special Issue Platelet Function and Platelet Proteomics in Ageing-Related Diseases)
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