Lysosomal Ion Channels in Cell Physiology and Human Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (1 January 2022) | Viewed by 490
Special Issue Editor
Interests: molecular and genetic physiology; ion channel; transporters; calcium signalling; autophagy; lysosomes; lysosomal storage diseases; neurodegenerative diseases; cancer
Special Issue Information
Dear Colleagues,
The physiology and functions of ion channels in the plasma membrane have been extensively studied. Due to the inaccessibility of intracellular membranes, our understanding of organellular ion channels is largely hampered. Recent developments in biomedical methodology have led to the identification of a plethora of ion channels in the membrane of lysosome. By regulating ion flux across lysosomal membrane, lysosomal ion channels are implicated in cell signaling, nutrient sensing, membrane trafficking, autophagy, gene expression, and organellar communication. Dysfunction of lysosomal ion channels has been associated with numerous human diseases, including lysosomal storage diseases, neurodegenerative diseases, infectious diseases, and cancer. This Special Issue is devoted to publishing original research articles and review papers focusing on the role of lysosomal ion channels in cell physiology and human diseases. We cordially invite you to contribute an article on any aspects related to the theme of this Special Issue.
Dr. Xianping Dong
Guest Editor
Manuscript Submission Information
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Keywords
- lysosome
- lysosomal ion channel
- calcium signalling
- nutrient sensing
- lysosomal membrane trafficking
- autophagy
- lysosomal storage disease
