Growth Factors and Stem Cells in Development, Homeostasis, Disease and Repair after Injury
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 614
Special Issue Editors
2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China
Interests: molecular pharmacology; biomaterials; growth factor; autophagy
Special Issues, Collections and Topics in MDPI journals
Interests: lung development and regeneration/repair; fibroblast growth factors; epithelial stem cells; resident stromal niche; lipofibroblasts; fibrosis
Special Issues, Collections and Topics in MDPI journals
Interests: tissue engineering; cell-scaffold interaction; mesoporous silica nanoparticles; dental pulp stem cells; bioceramics; surface characteristics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Fibroblast growth factors (FGFs) are a family of growth factors, which possess multifunctional proteins with a wide variety of effects, including cellular proliferation, survival, migration, and differentiation. FGFs are also critical in the tissue response to injury and repair, as shown in murine models. FGF signaling has been demonstrated to play an important role in development, homeostasis, disease, and repair after injury. At the cellular level, the secretion of FGFs plays a dual role in modulating fundamental cellular processes such as metabolism, proliferation, survival, migration, and differentiation of stem cells. On another hand, stem-cell-based tissue engineering has become more and more appealing to solve clinical challenges, including COVID-19. At the molecular level, cell-specific responses are triggered and the scaffold integration with the surrounding is enhanced. It has been shown that stem cells could “sense” the local environment and thus proliferate and differentiate accordingly. When it comes to applications in regenerative pharmacology and aging prevention, it is essential to provide stem cells with appropriate signaling to achieve the desired tissue engineering. An in-depth understanding of the mechanisms FGFs strategies use to affect stem cells and tissue regeneration will accelerate the tissue remodeling/regeneration progression and minimize the graft‐versus‐host reactions (immune and fibrotic responses). Both original research articles and reviews will be considered.
Dr. Zhouguang Wang
Guest Editor
Prof. Saverio Bellusci
Dr. Qingsong Ye
Co-Guest Editors
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Keywords
- growth factor
- stem cell
- regeneration medicine
- aging
- metabolism disease
- tissue engineering
- signaling pathways
- homeostasis
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