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Cells
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Extracellular Vesicle Subpopulations in Inflammation
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Extracellular Vesicle Subpopulations in Inflammation

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (15 July 2022) | Viewed by 8142

Special Issue Editor

Dr. Baharak Hosseinkhani

E-Mail Website
Guest Editor
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, 3000 Leuven, Belgium
Interests: vascular dysfunction; inflammation-associated disease; cancer; extracellular vesicle (EV) subpopulations; BBB disruption; cell migration; cell adhesion; EV omics; biosensor (EV on-chip); bio(nano)material
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Worldwide, nearly 60% of deaths is due to a chronic inflammatory diseases (CIDs) such as stroke, atherosclerosis, cancer, chronic respiratory diseases, arthritis, obesity, diabetes, and autoimmune diseases. At the pathobiology root of all of these life-affecting diseases, there is a chronic and pervasive state of inflammatory interactions between immune cells and others. So far, the communication of cells at the onset of inflammation is largely unknown.

Over the past few years, the discovery of extracellular vesicles (EV) has revolutionized the understanding of cell–cell communication in the development of CIDs. EV are submicron-sized membranous biological vesicles that are involved in the transport of a wide range of disease-specific biomarkers (lipids, proteins, m(i)RNAs) through biological fluids. Several studies now appreciate that the cargo of EV is a mirror of the physiological condition of the cell of origin and is tightly linked to the stage of inflammation-associated chronic diseases. Hence, increasing attention is given to the translational potential of EV as a reliable liquid biopsy for the diagnosis and monitoring of several CIDs.

In this Special Issue of Cells, I invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Extracellular Vesicle Subpopulations in Inflammation”. Expert articles describing the following topic are highly welcome:

  • Isolation and characterization of inflammation-associated EV subpopulations,
  • Cargo signature and functional integrity of EV at the onset of inflammation;
  • Tools to separate and characterize the disease-associated EV subtypes;
  • Cellular and molecular mechanisms of EV in CIDs;
  • Cytokine sorting and trafficking via EV;
  • EV Biomarker discovery.

Dr. Baharak Hosseinkhani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chronic inflammatory diseases
  • Inflammation
  • Extracellular vesicles
  • EV isolation and characterization

Published Papers (2 papers)

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Research

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18 pages, 3717 KiB  
Article
Vesicular MicroRNA as Potential Biomarkers of Viral Rebound
by Wilfried Wenceslas Bazié, Julien Boucher, Isidore Tiandiogo Traoré, Dramane Kania, Diane Yirgnur Somé, Michel Alary and Caroline Gilbert
Cells 2022, 11(5), 859; https://doi.org/10.3390/cells11050859 - 02 Mar 2022
Cited by 6 | Viewed by 1949
Abstract
Changes in the cellular microRNA (miRNA) expression profile in response to HIV infection, replication or latency have been reported. Nevertheless, little is known concerning the abundance of miRNA in extracellular vesicles (EVs). In the search for a reliable predictor of viral rebound, we [...] Read more.
Changes in the cellular microRNA (miRNA) expression profile in response to HIV infection, replication or latency have been reported. Nevertheless, little is known concerning the abundance of miRNA in extracellular vesicles (EVs). In the search for a reliable predictor of viral rebound, we quantified the amount of miR-29a, miR-146a, and miR-155 in two types of plasma extracellular vesicles. Venous blood was collected from 235 ART-treated and ART-naive persons living with HIV (85 with ongoing viral replication, ≥20 copies/mL) and 60 HIV-negative participants at five HIV testing or treatment centers in Burkina Faso. Large and small plasma EVs were purified and counted, and mature miRNA miR-29a, miR-146a, and miR-155 were measured by RT-qPCR. Diagnostic performance of miRNA levels in large and small EVs was evaluated by a receiver operating characteristic curve analysis. The median duration of HIV infection was 36 months (IQR 14–117). The median duration of ART was 34 months (IQR 13–85). The virus was undetectable in 63.8% of these persons. In the others, viral load ranged from 108 to 33,978 copies/mL (median = 30,032). Large EVs were more abundant in viremic participants than aviremic. All three miRNAs were significantly more abundant in small EVs in persons with detectable HIV RNA, and their expression levels in copies per vesicle were a more reliable indicator of viral replication in ART-treated patients with low viremia (20–1000 copies/mL). HIV replication increased the production of large EVs more than small EVs. Combined with viral load measurement, quantifying EV-associated miRNA abundance relative to the number of vesicles provides a more reliable marker of the viral status. The expression level as copies per small vesicle could predict the viral rebound in ART-treated patients with undetectable viral loads. Full article
(This article belongs to the Special Issue Extracellular Vesicle Subpopulations in Inflammation)
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Review

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23 pages, 14022 KiB  
Review
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
by Thu Huyen Nguyen, Chau Minh Duong, Xuan-Hung Nguyen and Uyen Thi Trang Than
Cells 2021, 10(11), 2887; https://doi.org/10.3390/cells10112887 - 26 Oct 2021
Cited by 19 | Viewed by 5382
Abstract
Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it [...] Read more.
Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has been shown that trophic factors enveloped in extracellular vesicles (EVs), including exosomes, are a crucial aspect of MSC-based treatment for OA. Evidently, EVs derived from different MSC sources might rescue the OA phenotype by targeting many biological processes associated with cartilage extracellular matrix (ECM) degradation and exerting protective effects on different joint cell types. Despite this advancement, different studies employing EV treatment for OA have revealed reverse outcomes depending on the EV cargo, cell source, and pathological condition. Hence, in this review, we aim to summarize and discuss the possible effects of MSC-derived EVs based on recent findings at different stages of OA development, including effects on cartilage ECM, chondrocyte biology, osteocytes and bone homeostasis, inflammation, and pain management. Additionally, we discuss further strategies and technical advances for manipulating EVs to specifically target OA to bring the therapy closer to clinical use. Full article
(This article belongs to the Special Issue Extracellular Vesicle Subpopulations in Inflammation)
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